Publications by authors named "Francesco Centofanti"
Introduction: Spondylodiscitis (SD) is an uncommon disease but not rare, because it represents around 3-5% of all cases of osteomyelitis. Late diagnosis and/or inadequate treatment often cause irreversible damage to cause neurological deficit. Most require only conservative treatment, sometimes a surgical approach is required.
View Article and Find Full Text PDFHypokalemia during antibiotic treatment for bone and joint infections.
Eur J Orthop Surg Traumatol
April 2018
Purpose: During treatment of bone and joint infections (BJIs) with multiple antibiotic therapy, hypokalemia has been reported as a rare side effect. The aim of this study was to evaluate incidence and risk factors for hypokalemia in a cohort of patients treated with multidrug therapy for BJIs, in a single center.
Methods: We retrospectively reviewed 331 clinical files of 150 consecutive patients (65% males; median age 59 years, 95% CI 55-62) admitted repeatedly to our Osteomyelitis Department for treatment of chronic BJIs.
Article Synopsis
- This study aimed to compare pre-made antibiotic-loaded spacers with two commercial antibiotic agents and custom-made cements with three added antibiotics, focusing on effectiveness, infection control, complications, and patient satisfaction.
- A cohort of 112 patients was analyzed, divided equally between those receiving a pre-formed cement spacer with two antibiotics and a spacer loaded with three antibiotics, with a follow-up period averaging 32.87 months.
- Findings indicated a low infection recurrence rate of 2.70% and suggested that using spacers loaded with three antibiotics is beneficial for patients at risk of multi-resistant infections, potentially reducing the need for further surgical interventions.