Publications by authors named "Francesco Carrozzo"
Antioxidants (Basel)
July 2024
Article Synopsis
- Organogenesis in the uterus occurs under low oxygen levels, but preterm birth exposes infants to high oxygen, which can harm organ development and lead to conditions like necrotizing enterocolitis.
- The study investigates the role of the β3-adrenoreceptor (β3-AR) in protecting the ileum from damage caused by high oxygen levels in newborn rat pups, using a selective β3-AR agonist, BRL37344.
- Results show that a 3 mg/kg dose of BRL37344 mitigates some harmful changes caused by hyperoxia, highlighting its potential as a therapeutic approach for addressing complications related to premature birth and excessive oxygen exposure.
Biomolecules
December 2023
Article Synopsis
- Oxygen levels play a crucial role in organ development, and changes in these levels after birth can significantly affect organs like the intestine that don’t fully mature in the womb.
- This study investigates the β3-adrenoreceptor (β3-AR) agonist BRL37344 in a neonatal rat model exposed to high oxygen levels, finding that hyperoxia negatively impacts colon development by reducing certain cell types and mucin production.
- Administering a specific dose of BRL37344 (3 mg/kg) helped prevent some of these negative effects, suggesting potential therapeutic benefits for conditions resulting from too much oxygen exposure in premature infants.
