Publications by authors named "Francesco Caprioglio"

Article Synopsis
  • The FAITAVI study is investigating how to best treat coronary artery disease in patients with severe aortic valve stenosis who are undergoing transcatheter aortic valve implantation (TAVI), comparing angiography-guided and physiology-guided strategies.
  • The study involves 320 participants across 15 sites in Italy and focuses on determining when to perform percutaneous coronary intervention (PCI) based on specific physiological measurements like fractional flow reserve (FFR).
  • Patients will be monitored for 24 months post-procedure to evaluate outcomes related to serious complications such as death, heart attack, and stroke, aiming to define a more effective approach to treatment.
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  • Limited research exists on pulsed-field ablation (PFA) for patients with persistent atrial fibrillation (PeAF) undergoing left atrial posterior wall isolation (LAPWI), as highlighted in a study involving 249 patients across 9 Italian centers.
  • The study found that LAPWI was successfully performed in 57.6% of cases without any major complications, and only 2.4% experienced minor issues.
  • Results indicated that PFA is a feasible and rapid method for LAPWI, providing effective outcomes without significantly increasing procedural times, making it a promising option for PeAF treatments.
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  • The first case of pulsed-field ablation (PFA) for treating focal atrial tachycardia (FAT) in a pediatric patient, specifically an 11-year-old girl with obesity, is presented.
  • The procedure involves targeting the earliest atrial activation in the left superior pulmonary vein and is noted to have a lower success and higher complication rate compared to standard radiofrequency ablation (RFA) in adults.
  • PFA is shown to effectively restore stable sinus rhythm after treatment, highlighting its potential as a safer alternative for young patients with FAT, minimizing the risk of complications associated with traditional methods.
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A 34-year-old man with unremarkable past medical history presents with night sweats and a recent diagnosis of intracardiac mass. The initial diagnostic workup did not provide a definitive diagnosis, so a cardiac biopsy under intracardiac echocardiography guidance was performed, revealing a hemangioma, which was then successfully resected. ().

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Modern cardiac pacemakers are equipped with a function that allows the heart rate to adapt to the current needs of the patient in situations of increased demand related to exercise and stress ("rate-response" function). This function may be based on a variety of mechanisms, such as a built-in accelerometer responding to increased chest movement or algorithms sensing metabolic demand for oxygen, analysis of intrathoracic impedance, and analysis of the heart rhythm (Q-T interval). The latest technologies in the field of rate-response functionality relate to the use of an accelerometer in leadless endocavitary pacemakers; in these devices, the accelerometer enables mapping of the mechanical wave of the heart's work cycle, enabling the pacemaker to correctly sense native impulses and stimulate the ventricles in synchrony with the cycles of atria and heart valves.

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Background: Intracardiac echocardiography (ICE) is increasingly used to guide left atrial appendage closure (LAAC).

Objectives: The aim of this study was to investigate the efficacy and safety of ICE-guided LAAC with the Watchman FLX device.

Methods: The ICE LAA (I Can See Left Atrial Appendage) study was a prospective, multicenter study with independent adjudication of echocardiographic data by a core laboratory and clinical events by a clinical events committee.

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Failure of the native aortic valve and degenerative anatomy of ascending aorta in patients with previous Tirone-David operation may represent a clinical challenge, because sometimes the risk of reoperation is prohibitive. We described the case of a patient suffering from severe aortic valve regurgitation and pseudoaneurysm of the aortic arch, 6 years after cardiac surgery operation. The aim of this clinical case was to assess if the complex anatomy of aortic pseudoaneurysm and aortic root geometry can be accurately reproduced from contrast-enhanced computed tomography scan into a three-dimensional (3D) printed model.

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Article Synopsis
  • * Out of 406 patients, 56.4% were treated for cardiogenic shock (CS) and 43.6% for high-risk percutaneous coronary intervention (HR-PCI); DRCs occurred in 25.6% of patients, with a significantly higher incidence in the CS group (37.1%) compared to the HR-PCI group (10.7%).
  • * The findings suggest that while CS is a strong predictor of DRCs, DRCs themselves do not independently predict
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Background: Redo surgical mitral valve replacement (SMVR) is the current standard of care for patients with failed bioprosthetic mitral valve (MV). Transcatheter mitral valve-in-valve replacement (TMViV) is arising as an alternative to SMVR in high risk patients. We sought to evaluate procedural safety, early and mid-term outcomes of patients who underwent transseptal TMViV (TS-TMViV), transapical TMViV (TA-TMViV), or redo-SMVR.

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  • De Winter's pattern (dWp) can complicate the diagnosis of STEMI, which is often crucial for timely treatment.
  • A case study highlights a man who experienced dWp after chest pain and developed cardiogenic shock, emphasizing the need for fast intervention despite successful revascularization.
  • This situation stresses the importance of quickly identifying dWp as a serious indicator for STEMI to ensure effective patient management and address potential complications.
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  • Patients with severe aortic stenosis and coronary artery disease were analyzed to compare outcomes between FFR-guided and angiography-guided revascularization during transcatheter aortic valve implantation.
  • The study found that FFR-guided revascularization had a higher rate of event-free survival (92.6%) compared to angiography-guided (82.0%) at a 2-year follow-up.
  • A significant number of lesions in the FFR group were considered negative for intervention based on the conventional threshold, suggesting that FFR can lead to better clinical outcomes than traditional angiography methods.
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  • Transcatheter aortic valve implantation (TAVI) has transformed how patients with severe aortic stenosis are treated, becoming the go-to option for those who can't undergo surgery and preferred for higher-risk patients.
  • Advances in technology and experience have led to an updated position paper by the Italian Society of Interventional Cardiology on TAVI practices.
  • The document aims to guide institutions and operators in evaluating their ability to effectively launch and sustain a TAVI program.
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  • Intravascular ultrasound is frequently used to optimize stent size in Left Main (LM) stenting, but many procedures still rely on traditional angiography, leading to potential inaccuracies.
  • This study analyzed records from 73 patients to compare outcomes of stenting using standard quantitative coronary angiography (QCA) versus QCA enhanced with the Finet Law, which improves stent-sizing accuracy.
  • Results indicated that patients who had stenting guided by QCA-Finet had significantly larger stent diameters and better long-term cardiovascular outcomes compared to those guided by standard QCA methods.
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Background: Infective endocarditis (IE) is still a condition with high mortality and morbidity, especially in the elderly, and in patients with prosthetic valves. The concept of "time-to-therapy" plays a key role for the prompt management of IE and related complications, and the currently available multimodality imaging may play a key role in this setting. Myocardial ischemia due to extrinsic coronary compression from an aortic abscess is an extremely rare condition where the optimal therapeutic strategy has not been defined yet.

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Article Synopsis
  • The study evaluates the effectiveness of two diagnostic methods, instantaneous wave-free ratio (iFR) and fractional flow reserve (FFR), for assessing coronary artery disease (CAD) in patients with severe aortic stenosis (AS).
  • It involved measuring 179 coronary lesions in 85 AS patients and comparing the results to a control group of 167 CAD patients without AS to see how well iFR and FFR correlated.
  • Findings show that while the correlation between iFR and FFR was similar in both groups, the standard iFR threshold was less effective in AS patients, suggesting that AS affects how we interpret iFR results and indicates the need for more research.
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  • The study investigates the combined use of Drug Eluting Stents (DES) and bioresorbable scaffolds (BVS) for treating long diffuse lesions in the left anterior descending coronary artery (LAD) using a new "edge-to-edge" technique.
  • A total of 23 patients were treated, with a follow-up of over 11 months, and the results showed no instances of stent thrombosis or major adverse cardiological events (MACE).
  • The findings suggest that the edge-to-edge implantation method is a safe and effective option for revascularizing long diffuse LAD disease, with promising short-term outcomes.
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Background: Coronary bifurcation lesions represent a difficult problem regularly confronting interventional cardiologist, in part due to the lack of dedicated device.

Objective: To investigate the feasibility, safety and effectiveness of the Tryton Side Branch Stent (Tryton Medical, Durham, NC, USA), a dedicated bare metal stent deployed in conjunction with a standard drug-eluting stent to treat bifurcation lesions.

Methods: The SAFE-TRY is a prospective single arm multicenter registry including patients with de novo bifurcation lesions in native coronary arteries and syntax score <32.

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Article Synopsis
  • - The study aimed to compare three different pacemaker modes (VVI, VVIR, and DDD) in patients needing dual-chamber stimulation, focusing on those with varying left ventricular function.
  • - Two patient groups were analyzed based on their heart function, with assessments on quality of life (QoL), patient preference, and echocardiographic parameters after being switched between modes.
  • - Results showed that most patients preferred the DDD mode, which also correlated with better QoL and significant improvements in health outcomes compared to VVI and VVIR modes.
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