Publications by authors named "Francesca Viale"
Article Synopsis
- * The study introduces a new delivery system using 150-nm liposomes to enhance the effectiveness of Givinostat, a pan-HDAC inhibitor, by improving its half-life in the bloodstream and increasing its delivery to the brain.
- * In vitro and in vivo results showed that these liposome-Givinostat formulations effectively inhibited glioblastoma cell growth and enhanced drug delivery without causing noticeable toxicity, suggesting they hold promise for future glioblastoma therapies.
Glioblastoma (GBM) is a particularly challenging brain tumor characterized by a heterogeneous, complex, and multicellular microenvironment, which represents a strategic network for treatment escape. Furthermore, the presence of GBM stem cells (GSCs) seems to contribute to GBM recurrence after surgery, and chemo- and/or radiotherapy. In this context, intercellular communication modalities play key roles in driving GBM therapy resistance.
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