Publications by authors named "Francesca R Noto"
Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global health concern with no effective and specific drug treatment available. The rs2642438 minor allele in mitochondrial amidoxime-reducing component 1 (MARC1) results in an aminoacidic substitution (p.Ala165Thr) and associates with protection against MASLD.
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- Steatotic liver disease (SLD) is the most common chronic liver condition, but there's no approved treatment due to unclear causes.
- Elevated levels of interleukin 32 (IL-32) are linked to severe SLD, with research showing that IL-32β increases fat synthesis in liver cells while reducing it when IL32 is decreased.
- A genetic variant (rs76580947) of IL32 is associated with lower IL-32 levels and may offer protection against SLD, indicating that reducing IL32 could be a potential therapeutic approach.
Background: C-peptide therapy exerts several positive actions on nerves, vasculature, smooth muscle relaxation, kidney function and bone. To date, the role of C-peptide in preventing type 1 diabetes-related muscle atrophy has not been investigated. Our aim was to evaluate if C-peptide infusion prevents muscle wasting in diabetic rats.
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