Publications by authors named "Francesca Pavani"
Article Synopsis
- This study examines the relationship between resting heart rate and cardiovascular diseases, identifying 493 genetic variants linked to this trait through a large-scale analysis of 835,465 individuals.
- It highlights the significance of higher genetically predicted resting heart rates, which are associated with an increased risk of dilated cardiomyopathy but lower risk for conditions like atrial fibrillation and ischemic strokes.
- The study also challenges previous findings on resting heart rate and all-cause mortality, suggesting earlier results may have been influenced by biases, ultimately enhancing our understanding of the biological implications of resting heart rate in cardiovascular health.
Article Synopsis
- Homozygosity, which often arises from inbreeding and is linked to rare disorders, has now been studied in relation to various health traits using genomic data from a large cohort of over 354,000 individuals.
- Significant associations were found between runs of homozygosity and traits like height, lung capacity, cognitive ability, and educational attainment, indicating that increased homozygosity leads to decreased values in these traits.
- The research suggests that increased stature and cognitive function have likely been positively selected in human evolution, contrasting earlier findings that found no link between homozygosity and some cardio-metabolic traits.
Low-frequency ultrasounds (US) are used to enhance drug transdermal transport. Although this phenomenon has been extensively analyzed, information on US effects on the single skin cell components is limited. Here, we investigated the possible effects of low-frequency US on viability and immune functions of cultured human keratinocytes and dendritic cells (DC), skin cells involved in the regulation of many immune-mediated dermatoses.
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