Impact of graft-versus-lymphoma effect on outcomes after reduced intensity conditioned-alemtuzumab allogeneic haematopoietic stem cell transplantation for patients with mature lymphoid malignancies.

Allogeneic haematopoietic stem cell transplant (allo-HSCT) offers potentially curative therapy for patients with relapsed/refractory lymphoid malignancies. Reduced-intensity conditioning (RIC) with Alemtuzumab reduces transplant-related mortality and graft-versus-host disease (GvHD), but may be associated with increased risk of relapse. With the aim of studying the effect of GVHD and donor lymphocyte infusions (DLI) on relapse, we performed a retrospective study of 288 patients (57% non-Hodgkin lymphoma, 24% Hodgkin lymphoma and 19% chronic lymphocytic leukaemia; 58% were relapsed/refractory) who underwent RIC-Alemtuzumab-HSCT between 2000 and 2012.

Coping with cancer: a brief report on stress and coping strategies in medical students dealing with cancer patients.

Background: This pilot study explored factors associated with stress in medical students during their initial clinical contact with cancer patients, in particular identifying stress levels and coping strategies used.

Methods: A total of 80 medical students at The University of Birmingham Medical School, UK, completed retrospective self-report questionnaires measuring socio-demographics, potential stressors and coping strategies (using the Brief COPE inventory). Statistical analysis followed data collection.