Malignant germ cell tumors in childhood: results of the first Italian cooperative study "TCG 91".

Background And Aims: About 20% of patients with germ cell tumor (GCT) are still resistant to therapy. To investigate which features are present in resistant patients, a multicenter study on GCT in children was undertaken to correlate clinical and laboratory parameters with the outcome.

Methods: Patients aged less than 16 years, with histologically proven extracranial GCT were included.