Publications by authors named "Francesca Liva"
ADAMTS-5 is a major protease involved in the turnover of proteoglycans such as aggrecan and versican. Dysregulated aggrecanase activity of ADAMTS-5 has been directly linked to the etiology of osteoarthritis (OA). For this reason, ADAMTS-5 is a pharmaceutical target for the treatment of OA.
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- Advanced age-related macular degeneration (AMD) is a leading cause of blindness among the elderly, with limited treatment options and characterized by loss of photoreceptors and dysfunctional Retinal Pigment Epithelium (RPE).
- The balance between matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) is crucial for maintaining extracellular matrix (ECM) integrity, and dysregulation of this balance can contribute to the development of AMD.
- The article reviews the role of zinc metalloproteinases in AMD, discusses current MMP inhibitors, and suggests their potential as therapeutic agents for treating the disease.