Publications by authors named "Francesca L Cox"
Redox Biol
September 2018
Article Synopsis
- Carbon monoxide-releasing molecules (CORMs) are primarily metal carbonyl compounds used to deliver CO, a gasotransmitter, in biological studies, and show promise as antimicrobial agents against bacteria like Escherichia coli.
- Research indicates that the antimicrobial effect of CORM-3 is mainly due to Ru(II), which binds to thiols, offering protection to both bacteria and mammalian cells through interactions with amino acids such as cysteine and reduced glutathione (GSH).
- The study reveals a strong correlation between the binding affinities of amino acids and their ability to protect cells from CORM-3, suggesting a need to reconsider the biological impacts of CORMs in light of these findings.
