Harnessing graphene oxide nanocarriers for siRNA delivery in a 3D spheroid model of lung cancer.

Gene therapy has been recently proposed as an effective strategy for cancer treatment. A significant body of literature proved the effectiveness of nanocarriers to deliver therapeutic agents to 2D tumour models, which are simple but not always representative of the reality. In this study, we analyze the efficiency of 3D spheroids combined with a minimally modified graphene oxide (GO)-based nanocarrier for siRNA delivery as a new system for cell transfection.

Decellularized fennel and dill leaves as possible 3D channel network in GelMA for the development of an adipose tissue model.

The development of 3D scaffold-based models would represent a great step forward in cancer research, offering the possibility of predicting the potential response to targeted anticancer or anti-angiogenic therapies. As regards, 3D models require proper materials, which faithfully recapitulated extracellular matrix (ECM) properties, adequate cell lines, and an efficient vascular network. The aim of this work is to investigate the possible realization of an 3D scaffold-based model of adipose tissue, by incorporating decellularized 3D plant structures within the scaffold.

Characteristics of Graphene Oxide for Gene Transfection and Controlled Release in Breast Cancer Cells.

Functionalized graphene oxide (GO) nanoparticles are being increasingly employed for designing modern drug delivery systems because of their high degree of functionalization, high surface area with exceptional loading capacity, and tunable dimensions. With intelligent controlled release and gene silencing capability, GO is an effective nanocarrier that permits the targeted delivery of small drug molecules, antibodies, nucleic acids, and peptides to the liquid or solid tumor sites. However, the toxicity and biocompatibility of GO-based formulations should be evaluated, as these nanomaterials may introduce aggregations or may accumulate in normal tissues while targeting tumors or malignant cells.

Thermophysical and mechanical properties of biological tissues as a function of temperature: a systematic literature review.

Background: Detailed information on the temperature dependence of tissue thermophysical and mechanical properties is pivotal for the optimal implementation of mathematical models and simulation-based tools for the pre-planning of thermal ablation therapies. These models require in-depth knowledge of the temperature sensitivity of these properties and other influential terms (e.g.