Publications by authors named "Francesca Giorgolo"
Article Synopsis
- - The study investigates the relationship between various lifestyle exposures (the exposome) and genetic factors in the risk of developing pancreatic ductal adenocarcinoma (PDAC), using a large case-control analysis from the UK Biobank.
- - Researchers identified 52 significant associations with PDAC risk, reaffirming known factors like smoking and obesity, while also discovering potential links between mobile phone use, stress, and the disease.
- - Despite the connection between genetic predisposition and PDAC risk, the study found no significant interactions between genetic and environmental factors, suggesting that lifestyle choices may have a more substantial impact on risk.
Article Synopsis
- - The study explores how local environmental factors, such as air quality and proximity to the coast, potentially influence cancer susceptibility, particularly focusing on prostate cancer and its relationship with physical activity and outdoor time.
- - Using data from the UK Biobank, researchers analyzed 12 environmental exposures and their associations with various cancers in a large cohort, revealing 36 significant links and suggesting that individuals living farther from the coast had an increased risk of prostate cancer.
- - Findings indicate that while genetic factors do play a role, local environmental factors and genetic variability contribute to cancer risk independently, highlighting the complex interplay between our surroundings and genetics in cancer development.
Inherited muscular dystrophies and congenital myopathies present in early childhood with progressive muscle weakness, determining severe motor limitations. Active surveillance and management of associated complications have improved ambulation, function, quality of life and life expectancy. The need for repeatable, objective and quantitative measures to monitor the clinical course of the disease is a current issue, particularly in the new era where new flows of therapies are proposed to the patients.
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