Charcot-Marie-Tooth disease associated with recurrent optic neuritis.

The factors precipitating central nervous system (CNS) demyelination, including optic neuritis, remain largely unknown but are likely to represent a complex interplay between the patient's environment and their genetic background. We report the development of sequential demyelinating optic neuritis in a patient with genetically confirmed Charcot-Marie-Tooth disease type 1A, a hereditary neuropathy. This neuropathy is characterized by duplication of peripheral myelin protein 22 (PMP22), which results in structurally abnormal peripheral myelin.

Effect of the angle of the operating microscope light beam on visual recovery after phacoemulsification: Randomized trial.

Purpose: To evaluate differences in visual recovery after phacoemulsification with direct or tilted surgical microscope illumination using a macular photostress test.

Setting: Western Eye Hospital, Imperial College Health Care National Health Service Trust, London, United Kingdom.

Methods: This randomized double-masked controlled trial enrolled patients presenting to a daycare unit for single-eye cataract surgery.