Publications by authors named "Francesca Di Gregorio"
The application of a multidisciplinary approach in the diagnosis of Castleman disease and Castleman-like lymphadenopathies: A 20-year retrospective analysis of clinical and pathological features.
Br J Haematol
February 2024
Background: Castleman disease (CD) comprises a group of rare and heterogeneous haematological disorders, including unicentric (UCD) and multicentric (MCD) forms, the latter further subdivided into HHV8-MCD, POEMS-MCD and idiopathic-MCD (iMCD). However, according to the Castleman Disease Collaborative Network guidelines, the diagnosis of CD can only be achieved through collaboration between clinicians and pathologists.
Methods: We applied these clinical and pathological criteria and implement with clonality testing to a retrospective cohort of 48 adult and paediatric Italian patients diagnosed with reactive lymphadenitis with CD-like histological features.
Article Synopsis
- Lymphoma treatments often lead to negative side effects that can lower patients' quality of life (QoL), especially in those aged 65 and older who may experience faster aging effects.* -
- A study included 30 lymphoma patients aged 18-80, dividing them into an Interventional Group (IG) that engaged in Exercise-Training (ET) during treatment and a Reference Group (RG) that did not.* -
- The IG showed significant improvements in cardiorespiratory fitness and QoL by the end of the study, suggesting that supervised ET is both safe and beneficial during chemotherapy, even for older patients.*
Purpose: Peripheral T cell lymphomas (PTCLs) have an overall poor prognosis. Indeed, registry data in elderly patients show that the median progression-free survival (mPFS) following first- and second-line therapies are only 6.7 and 3.
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