Real-Time Multi-Ion-Monitoring Front-End With Interference Compensation by Multi-Output Support Vector Regressor.

Ion-sensors play a major role in physiology and healthcare monitoring since they are capable of continuously collecting biological data from body fluids. Nevertheless, ion interference from background electrolytes present in the sample is a paramount challenge for a precise multi-ion-monitoring. In this work, we propose the first system combining a battery-powered portable multi-channel electronic front-end, and an embedded Multi-output Support Vector Regressor (M-SVR), that supplies an accurate, continuous, and real-time monitoring of sodium, potassium, ammonium, and calcium ions.

Continuous monitoring of propofol in human serum with fouling compensation by support vector classifier.

We present a new method for electrochemical sensing, which compensates the fouling effect of propofol through machine learning (ML) model. Direct and continuous monitoring of propofol is crucial in the development of automatic systems for control of drug infusion in anaesthesiology. The fouling effect on electrodes discourages the possibility of continuous online monitoring of propofol since polymerization of the surface produces sensor drift.

Fast Procedures for the Electrodeposition of Platinum Nanostructures on Miniaturized Electrodes for Improved Ion Sensing.

Nanostructured materials have attracted considerable interest over the last few decades to enhance sensing capabilities thanks to their unique properties and large surface area. In particular, noble metal nanostructures offer several advantages including high stability, non-toxicity and excellent electrochemical behaviour. However, in recent years the great expansion of point-of-care (POC) and wearable systems and the attempt to perform measurements in tiny spaces have also risen the need of increasing sensors miniaturization.

A novel electrochemical sensor for non-invasive monitoring of lithium levels in mood disorders.

Lithium is the main drug for the treatment of mood disorders. Due to its narrow therapeutic window, Therapeutic Drug Monitoring (TDM) is a norm during therapy in order to avoid adverse effects. Consequently, patients are obliged to frequent check-ups in hospitals to determine their serum concentration and optimize accordingly the drug dose.