Plasmin-Binding Tripeptide-Decorated Liposomes Loading Pyrazolo[3,4-]pyrimidines for Targeting Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is one of the most fatal cancer types worldwide. HCC cells were proved to overexpress c-Src and Sgk1, a tyrosine and a serine-threonine kinase, respectively, whose role is crucial for the development and progression of the tumor. Pyrazolo[3,4-]pyrimidine derivatives are a class of tyrosine kinase inhibitors that have shown good activity against HepG2.