Loss of cutaneous large and small fibers in naive and l-dopa-treated PD patients.

Objective: To study small and large fiber pathology in drug-naive and l-dopa-treated patients affected by Parkinson disease (PD) in early phases, before the occurrence of neuropathic electrophysiologic abnormalities.

Methods: We enrolled 85 patients with idiopathic PD (male/female 49/36, age 61.3 ± 9.

Intracranial extension of orbital inflammatory pseudotumor: a case report and literature review.

Background: Orbital inflammatory pseudotumor is a rare inflammatory condition of unknown cause that may extend intracranially, usually as a dural-based infiltrate. Here we report the first case of orbital pseudotumor presenting with intra-axial Magnetic Resonance Imaging (MRI) changes.

Case Presentation: A 57-year-old white female, with a 3-month history of headache and right palpebral edema, presented with marked right temporal lobe edema with ominous MRI appearance, and ipsilateral alterations of orbital and periorbital structures.

Cutaneous sensory and autonomic denervation in CADASIL.

Objective: To assess the involvement of the peripheral nervous system in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) by means of immunofluorescence and confocal analysis of punch skin biopsies.

Methods: We recruited 14 unrelated patients with CADASIL (M/F = 9/5; age 53.9 ± 10.