Publications by authors named "Francesca Alletto"
Article Synopsis
- NAFLD (Non-alcoholic fatty liver disease) cases are rising globally, and the study aimed to see how the severity of liver, metabolic, and cardiovascular diseases has changed over time.
- Researchers analyzed 422 NAFLD patients diagnosed between 1990 and 2021, focusing on various health indicators and genetic factors across different decades.
- The findings revealed that more recent patients showed higher rates of diabetes, obesity, severe liver damage, and early signs of cardiovascular issues compared to earlier years, alongside an increase in a specific unfavorable genetic variant related to NAFLD.
Article Synopsis
- The COVID-19 lockdown led to significant lifestyle changes for people, particularly impacting diet and physical activity in patients with non-alcoholic fatty liver disease (NAFLD).
- A study of 357 NAFLD patients revealed that after the lockdown, 48% gained weight and 16% experienced a worsening of liver fat content, largely associated with poor adherence to a Mediterranean diet and reduced physical activity.
- Genetic factors, particularly the PNPLA3 GG genotype, were found to be significant independent predictors of weight gain and negative changes in metabolic health, highlighting the need to consider genetics in managing NAFLD during lifestyle changes.
An overview of deregulated lipid metabolism in nonalcoholic fatty liver disease with special focus on lysosomal acid lipase.
Am J Physiol Gastrointest Liver Physiol
October 2020
Obesity and type 2 diabetes are frequently complicated by excess fat accumulation in the liver, which is known as nonalcoholic fatty liver disease (NAFLD). In this context, liver steatosis develops as a result of the deregulation of pathways controlling de novo lipogenesis and fat catabolism. Recent evidences suggest the clinical relevance of a reduction in the activity of lysosomal acid lipase (LAL), which is a key enzyme for intracellular fat disposal, in patients with NAFLD.
View Article and Find Full Text PDFNon-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries and is associated with aging and features of metabolic syndrome. Lipotoxicity and oxidative stress are consequent to dysregulation of lipid metabolism and lipid accumulation, leading to hepatocyte injury and inflammation. Lipophagy consists in selective degradation of intracellular lipid droplets by lysosome and mounting evidence suggests that lipophagy is dysregulated in NAFLD.
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