Assessment of 2D conventional and synthetic MRI in multiple sclerosis.

Purpose: To qualitatively and quantitatively compare synthetic and conventional MRI sequences acquired on a 1.5-T system for patients with multiple sclerosis (MS).

Methods: Prospective study that involved twenty-seven consecutive relapsing-remitting MS patients scanned on a 1.

Assessment of automatic decision-support systems for detecting active T2 lesions in multiple sclerosis patients.

Background: Active (new/enlarging) T2 lesion counts are routinely used in the clinical management of multiple sclerosis. Thus, automated tools able to accurately identify active T2 lesions would be of high interest to neuroradiologists for assisting in their clinical activity.

Objective: To compare the accuracy in detecting active T2 lesions and of radiologically active patients based on different visual and automated methods.

Interferon β-1b for the treatment of primary progressive multiple sclerosis: five-year clinical trial follow-up.

Objectives: To investigate, during the 5-year period without treatment after termination of a 2-year clinical trial of interferon beta-1b for the treatment of primary progressive multiple sclerosis, differences in the evolution of clinical variables and magnetic resonance imaging results between trial arms and to investigate correlations between in-trial changes in Multiple Sclerosis Functional Composite (MSFC) score and magnetic resonance imaging variables and Expanded Disability Status Scale (EDSS) score evolution.

Design: Five-year clinical trial follow-up.

Setting: Clinical Neuroimmunology Unit, Multiple Sclerosis Centre of Catalonia, Autonomous University of Barcelona, Spain.