Publications by authors named "Francesc Carmona-Pontaque"
Article Synopsis
- A study on plant-based diets in a Danish population examined how these diets relate to metabolic syndrome (MetS) and identified specific metabolites linked to dietary patterns.
- The research involved 676 participants who provided dietary information and underwent health examinations, leading to the classification of diet quality using healthful (hPDI) and unhealthful (uPDI) indices.
- Findings showed that higher hPDI scores correlated with a decreased risk of MetS, while higher uPDI scores increased the risk, with specific metabolites identified as key indicators of these associations.
Article Synopsis
- Metabolomics and proteomics encounter challenges in data mining, particularly in statistical analysis, which is essential for biological interpretation and biomarker discovery.
- To aid in these analyses, bioinformatic tools have been developed, but many still rely on limited statistical methods and inflexible data sets.
- POMAShiny is a user-friendly web tool that enhances the statistical analysis and visualization of metabolomics and proteomics data, integrating various methods for improved reproducibility and flexibility, and is available for free online.
Background: Mutations in leucine rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease (PD). Mitochondrial and autophagic dysfunction has been described as etiologic factors in different experimental models of PD. We aimed to study the role of mitochondria and autophagy in LRRK2 -mutation, and its relationship with the presence of PD-symptoms.
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- - The study aimed to assess the impact of the macrophage molecule CD14 on insulin resistance by evaluating its effects in various mouse models and human adipose tissue.
- - Researchers found that introducing recombinant human soluble CD14 (rh-sCD14) improved insulin sensitivity in several mouse models, while CD14 knockout mice did not show these benefits, indicating a significant role for CD14 in regulating insulin action and gene expression related to lipid metabolism.
- - Results also suggested that CD14 influences inflammation in adipose tissue, as CD14 knockout mice exhibited resistance to insulin resistance when grafted with cells from other CD14 knockout mice, highlighting its potential link to obesity-related metabolic complications.