Multiple labelled nanoparticles for bio detection.

Remote nanoparticle detection is required for the development of in situ biological probes. Here we describe the labelling of silver nanoparticles to produce multiply coded particles which can be detected by surface enhanced resonance Raman scattering (SERRS). There is a potential for thousands of codes to be written and read without the need for spatial resolution of components of the code.

The first SERRS multiplexing from labelled oligonucleotides in a microfluidics lab-on-a-chip.

The first simultaneous detection of three dye-labelled oligonucleotides in a microfluidics chip by SERRS is reported.