Publications by authors named "Frances C Tinley"
Obesity underpins the development of numerous chronic diseases, such as type II diabetes mellitus. It is well established that obesity negatively alters immune cell frequencies and functions. Mucosal-associated invariant T (MAIT) cells are a population of innate T cells, which we have previously reported are dysregulated in obesity, with altered circulating and adipose tissue frequencies and a reduction in their IFN-γ production, which is a critical effector function of MAIT cells in host defense.
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- Gliotoxin is a powerful anti-fungal compound that can inhibit the growth of Aspergillus fumigatus, particularly when key enzymes (GliT and GtmA) are absent.
- Dithiol gliotoxin (DTG) chelates zinc ions (Zn2+), limiting their availability and affecting the function of zinc-dependent enzymes like alkaline phosphatase (AP).
- Increased levels of Zn2+ can counteract DTG's inhibitory effects on A. fumigatus and alter the expression of proteins related to secondary metabolism, suggesting a potential mechanism for mitigating gliotoxin's action in a biological context.