Cytokine release syndrome and immune effector cell‑associated neurotoxicity syndrome in a melanoma patient treated with adjuvant pembrolizumab.

The emergence of immune checkpoint inhibitors (ICIs) has significantly improved the prognosis of patients with solid tumors. However, along with their efficacy, new toxicities related to immune system activation have surfaced, some of which pose life-threatening risks. Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) are among the serious, albeit rare, immune-related adverse effects (irAEs) observed.

Good enough processing: what have we learned in the 20 years since Ferreira et al. (2002)?

Traditionally, language processing has been thought of in terms of complete processing of the input. In contrast to this, Ferreira and colleagues put forth the idea of good enough processing. The proposal was that during everyday processing, ambiguities remain unresolved, we rely on heuristics instead of full analyses, and we carry out deep processing only if we need to for the task at hand.

Integrating wet stirred-bead milling for Tetraselmis suecica biorefinery: Operating parameters influence and specific energy efficiency.

Stirred bead milling proved to be an efficient cell destruction technique in a biorefinery unit for the extraction of over 95 % of proteins and 60 % of carbohydrates from the green marine microalga Tetraselmis suecica. Optimum conditions, expressed in terms of metabolite yield and energy consumption, were found for average values of bead size and agitator rotation speed. The higher the microalgae concentration, up to 100 g.

Effects of irrelevant unintelligible and intelligible background speech on spoken language production.

Earlier work has explored spoken word production during irrelevant background speech such as intelligible and unintelligible word lists. The present study compared how different types of irrelevant background speech (word lists vs. sentences) influenced spoken word production relative to a quiet control condition, and whether the influence depended on the intelligibility of the background speech.

Automating weighing of faces and voices based on cue saliency in trustworthiness impressions.

When encountering people, their faces are usually paired with their voices. We know that if the face looks familiar, and the voice is high-pitched, the first impression will be positive and trustworthy. But, how do we integrate these two multisensory physical attributes? Here, we explore 1) the automaticity of audiovisual integration in shaping first impressions of trustworthiness, and 2) the relative contribution of each modality in the final judgment.

Neglected gaps in improving the health, wellbeing, and care for sexual and gender minority young people living in low- and lower-middle- income countries: a scoping review.

Background: There is a lack of reliable data on the size, characteristics, and experiences of sexual and gender minority (SGM) young people (ages 10-24) in low- and lower-middle- income countries (LMICs). This review examines the research conducted in the last thirteen years with and about SGM young people living in low-income settings and seeks to answer the question: What is known about the mental and physical health needs, safety, and wellbeing of SGM young people living in LMICs?

Methods: We conducted a scoping review informed by the methodological frameworks put forth by Arksey and O'Malley and the Joanna Briggs Institute. We systematically searched two general social science databases and one topic-specific database for peer-reviewed papers, of any research design, that included SGM young people or explored attitudes toward SGM young people in LMICs.

2023 ACR/EULAR antiphospholipid syndrome classification criteria.

Objective: To develop new antiphospholipid syndrome (APS) classification criteria with high specificity for use in observational studies and trials, jointly supported by the American College of Rheumatology (ACR) and EULAR.

Methods: This international multidisciplinary initiative included four phases: (1) Phase I, criteria generation by surveys and literature review; (2) Phase II, criteria reduction by modified Delphi and nominal group technique exercises; (3) Phase III, criteria definition, further reduction with the guidance of real-world patient scenarios, and weighting via consensus-based multicriteria decision analysis, and threshold identification; and (4) Phase IV, validation using independent adjudicators' consensus as the gold standard.

Results: The 2023 ACR/EULAR APS classification criteria include an entry criterion of at least one positive antiphospholipid antibody (aPL) test within 3 years of identification of an aPL-associated clinical criterion, followed by additive weighted criteria (score range 1-7 points each) clustered into six clinical domains (macrovascular venous thromboembolism, macrovascular arterial thrombosis, microvascular, obstetric, cardiac valve, and hematologic) and two laboratory domains (lupus anticoagulant functional coagulation assays, and solid-phase enzyme-linked immunosorbent assays for IgG/IgM anticardiolipin and/or IgG/IgM anti-β-glycoprotein I antibodies).

C-2 Thiophenyl Tryptophan Trimers Inhibit Cellular Entry of SARS-CoV-2 through Interaction with the Viral Spike (S) Protein.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, by infecting cells via the interaction of its spike protein (S) with the primary cell receptor angiotensin-converting enzyme (ACE2). To search for inhibitors of this key step in viral infection, we screened an in-house library of multivalent tryptophan derivatives. Using VSV-S pseudoparticles, we identified compound as a potent entry inhibitor lacking cellular toxicity.

Hybrid computational and real data-based positioning of small cells in 5G networks.

One of the key technologies in smart cities is the use of next generation networks such as 5G networks. Mainly because this new mobile technology offers massive connections in densely populated areas in smart cities, thus playing a crucial role for numerous subscribers anytime and anywhere. Indeed, all the most important infrastructure to promote a connected world is being related to next generation networks.

Cell destruction level and metabolites green-extraction of Tetraselmis suecica by low and intermediate frequency ultrasound.

Low (20 kHz) and intermediate (100 kHz) frequency ultrasound (US) were studied for their efficiency on cell destruction and metabolites extraction of the microalga T. suecica. This study revealed different levels of cell destruction.

Cutaneous vasculitis occurring in the setting of systemic lupus erythematosus: a multicentre cohort study.

Objectives: To describe the clinical and pathological features of biopsy-proven cutaneous vasculitis (CV) associated with SLE, focusing on diagnosis classification and impact on overall SLE activity.

Methods: Retrospective multicentric cohort study including SLE patients with biopsy-proven CV identified by (i) data from pathology departments of three university hospitals and (ii) a national call for cases. SLE was defined according to 1997 revised ACR and/or 2019 ACR/EULAR criteria.

Information-seeking across auditory scenes by an echolocating dolphin.

Dolphins gain information through echolocation, a publicly accessible sensory system in which dolphins produce clicks and process returning echoes, thereby both investigating and contributing to auditory scenes. How their knowledge of these scenes contributes to their echoic information-seeking is unclear. Here, we investigate their top-down cognitive processes in an echoic matching-to-sample task in which targets and auditory scenes vary in their decipherability and shift from being completely unfamiliar to familiar.

Performance accuracy, advantages and limitations of a store-and-forward teledermatology platform developed for general practitioners: A retrospective study of 298 cases.

Background: Store-and-forward (SAF) tele-dermatology (TD) platforms could help promote coordination between hospital and general practitioners (GPs). However, very little data exists on the performance accuracy and opinions of GPs participating in this type of project in France.

Methods: We report on the diagnostic and management plan accuracy of an SAF-TD platform developed for neighbouring GPs around our hospital compared with routine face-to-face (FTF) dermatological consultation in our department.

Speaker Accent Modulates the Effects of Orthographic and Phonological Similarity on Auditory Processing by Learners of English.

The cognate effect refers to translation equivalents with similar form between languages-i.e., cognates, such as "band" (English) and "banda" (Spanish)-being processed faster than words with dissimilar forms-such as, "cloud" and "nube.

An Analysis of the Deleterious Impact of the Infodemic during the COVID-19 Pandemic in Brazil: A Case Study Considering Possible Correlations with Socioeconomic Aspects of Brazilian Demography.

Due to COVID-19, a huge amount of incorrect information has been disseminated on the internet, which may interfere with the disease's advance. This study analyzes the behavior of the Brazilian population during the pandemic, employing queries of infodemic data searched on Google Trends and relating them to socioeconomic and political indicators in the country. The z-score technique was used to standardize the data; and for multivalued analysis, dendrograms and the Elbow method detected similar patterns among Brazilian states.