Alzheimer's Disease Biomarkers and Future Decline in Cognitive Normal Older Adults.

Background: Identifying older adults at risk of cognitive decline represents a challenge as Alzheimer's disease (AD) modifying therapies move toward preclinical stages.

Objective: To investigate the relationship between AD biomarkers and subsequent change in cognition in a cohort of cognitively intact older adults.

Methods: 84 cognitively normal subjects (mean age 72.