Publications by authors named "Frances A Jurnak"
Mol Cancer Ther
February 2009
Article Synopsis
- The study examines how hypermethylation, often linked to tobacco smoking, silences the Wnt antagonist WIF1, which plays a crucial role in inhibiting bladder cancer cell growth.
- Both restoring WIF1 expression and using a WIF1 protein led to growth inhibition in invasive bladder cancer cells by causing G(1) cell cycle arrest, associated with changes in key regulatory proteins like SKP2, c-myc, p21, and p27.
- The findings suggest that targeting SKP2 may offer new strategies for treating bladder cancer that loses WIF1 function, revealing important insights into tumor growth mechanisms in this context.
