Publications by authors named "Francelise B Cavassin"
Background: Progressive disseminated histoplasmosis is a significant issue in Latin America, particularly in Brazil, contributing to high mortality rates.
Objectives: Our objectives were to comprehensively describe histoplasmosis treatment with various amphotericin B (AmB) formulations, including mortality rates, adverse effects and risk factors for mortality.
Methods: This multicentre retrospective cohort study (January 2014-December 2019) evaluated medical records of patients with proven or probable histoplasmosis treated with at least two doses of AmB in seven tertiary medical centres in Brazil.
Effectiveness, Tolerability, and Safety of Different Amphotericin B Formulations in Invasive Fungal Infections: A Multicenter, Retrospective, Observational Study.
Clin Ther
April 2024
Purpose: Data on the real-life use of amphotericin B lipid complex (ABLC) compared with other available formulations are limited. This study aimed to evaluate the effectiveness, tolerability, and safety of different amphotericin B (AMB) intravenously administered in the context of hospital practice for the treatment of invasive fungal infections (IFI) and to provide new insights into the profile of ABLC.
Methods: This is a multicenter, retrospective, observational study conducted at 10 tertiary Brazilian hospitals.
Article Synopsis
- Zoonotic outbreaks of sporotrichosis in Brazil, particularly cat-transmitted sporotrichosis (CTS) from the fungus Sporothrix brasiliensis, are on the rise, with a significant increase in cases observed between 2011 and 2022 in Curitiba.
- In a review of 216 cases, the incidence rose dramatically from 0.3 to 21.4 cases per 100,000 outpatient visits over the decade, with 58% of cases occurring from 2019 to 2021.
- The most common form of sporotrichosis was lymphocutaneous, accounting for 63% of cases, highlighting the need for greater public awareness and preventive measures against transmission.
Background And Objective: Amphotericin B deoxycholate (AMB-D) remains an antifungal agent with great therapeutic value in pediatric patients. The currrent consensus is that its use in neonates is safer than in older children. However, childhood presents different periods of development that deserve to be evaluated more precisely.
View Article and Find Full Text PDFIntroduced in the late 1950s, polyenes represent the oldest family of antifungal drugs. The discovery of amphotericin B and its therapeutic uses is considered one of the most important scientific milestones of the twentieth century . Despite its toxic potential, it remains useful in the treatment of invasive fungal diseases owing to its broad spectrum of activity, low resistance rate, and excellent clinical and pharmacological action.
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