Synchronous primary endometrial and fallopian tube cancers.

Background: Synchronous primary cancers are relatively uncommon in the general population. We present a case of synchronous primary endometrial and fallopian tube cancers and review the literature.

Case: The patient, a 54-year-old, gravida 2, para 2 postmenopausal Greek woman presented with a complaint of abnormal vaginal bleeding.

The effects of prenatally administered endogenous cannabinoid on rat offspring.

We reported previously that the main psychoactive component of marihuana, delta9 tetrahydrocannabinol (THC), when injected prenatally, temporarily inhibited the developing hypothalamo-pituitary system in rat offspring. In the present study, we investigated the effects of the recently described endogenous ligand for the central cannabinoid receptor, arachidonyl-ethanolamide (anandamide, ANA), on the postnatal development of the hypothalamo-pituitary axis (HPA) when administered during the third week of gestation. Rat pups were killed every fifth day from delivery to the 20th postnatal day; gonads, pituitary, and rest of body were weighed, and samples were collected for analysis of gonadotropin releasing hormone in the hypothalamus and luteinizing hormone, follicle stimulating hormone, prolactin, and growth hormone in the pituitaries and sera.

Effects of anandamide on gestation in pregnant rats.

The present study was to test whether the recently described endogenous ligand for the cannabinoid receptor; arachidonyl-ethanolamide (anandamide, ANA), may produce similar effects on pregnancy as the main psychoactive component of marihuana: delta9-tetrahydrocannabinol (THC) in rats. ANA, THC (0.02 mg/kg i.