[An evaluation of the allergizing properties of merthiolate as a component of adsorbed DTP vaccine].

The study of the allergenic properties of thimerosal contained in adsorbed DPT vaccine was carried out. Two variants of this vaccine, with and without thimerosal, as well as thimerosal alone (diluted 1:10,000, which corresponds to the content of this preservative in the vaccine), were used in experiments. The phenomenon of anaphylactic shock, passive dermal anaphylaxis and skin tests were used as test-systems.

[Differential diagnosis and treatment of metatypic cancer].

Fifty one patients with metatypic carcinoma (MC), 10 with basalioma, and 10 with squamous cell carcinoma were clinically and immuno-morphologically studied. There were great differences in the localization of basal cell antigen in the epidermis during MC, basalioma, squamous carcinoma of the skin. Expression of fixed immunoglobulins A, M, G in tumor tissues revealed no significant differences.

[The use of Russian allergoids for the specific immunotherapy of pollinosis].

For three years 128 pollinosis patients received specific immunotherapy with cereals, weed and tree pollen allergens manufactured by the Scientific and Industrial Amalgamation "Allergen" (Stavropol). For comparison, a group of 42 patients was treated with the corresponding allergens according to the commonly used treatment scheme. Patients who had earlier undergone treatment with water-saline extracts of allergens, that proved to be ineffective, formed a special group.

[A comparative immunochemical analysis of allergoids and allergens].

In comparison with allergens having protein fragments with a molecular weight not exceeding 110 kD, allergoids have been found to consist of larger fragments with a molecular weight of 10-150 kD. Allergoids have less charged components than initial allergens and less antigenic components. Allergoids retain their capacity for stimulating the production of antibodies, specific to all antigenic components.

[The comparative characteristics of different forms of allergens from mites of the genus Dermatophagoides].

The comparative study of allergenic preparations of Dermatophagoides mites [correction of ticks] from different manufacturers and the international standard preparations of such allergens was made. D. pteronyssinus and D.

[Diagnosis of bacterial allergy in patients with diseases of the nose and paranasal sinuses].

A comprehensive allergological examinations of 92 patients with lesions of the nose and paranasal cavities and 20 essentially healthy subjects was carried out, using skin tests and neutrophil tests. Half of the patients showed sensitization to Staphylococcus aureus and Streptococcus pyogenes allergens, which occurred more frequently in patients with chronic purulent sinusitis. It is recommended to expose such patients to allergological examinations and to prescribe, if indicated, desensitization therapy.

[The immunochemical characteristics of allergens].

Modern approaches to the standardization of allergens require the use of not only biological methods, but also a wide range of physicochemical and immunological ones. To obtain Soviet standard samples, the optimum spectrum of methods for their characterization, evaluation and comparison with international standard samples should be definitely selected. After the preliminary study of a number of allergens by different immunochemical methods a set of such methods, including different kinds of electrophoresis, isoelectrofocusing, immunoblotting, etc.

[Evaluation of allergy to conditionally pathogenic fungi].

Sensitization to Candida albicans, Mucor, Cladosporium, Penicillium, Alternaria, Rhizopus nigricans was studied in vitro and in vivo in patients suffering from allergic diseases. The overwhelming majority of the positive responses to skin tests were of the immediate type. In parallel with the immediate responses, delayed ones were recorded in some patients.

[Use of isoelectric focusing for assessing the composition of pollen allergens].

The preparations of allergens and allergoids obtained from ragweed, timothy and wormwood pollen, as well as the preparations of allergens from birch and orchard grass pollen differing in the method of their production, have been studied with the use of analytical isoelectric focusing in a thin gel layer. The composition of the preparations of allergoids differs from that of the allergenic preparations from the pollen of the same plant species by the decreased content of protein components detected in this investigation. The main proteins contained in the preparations of allergoids are distributed in the zone of pH 3.

"Use of neutrophil damage index (NDI) test for allergy evaluation".

In the study the author presents the results of in vitro diagnosis of specific allergy by means of a new test. The data on the NDI (Neutrophile Damage Index) test were first published in 1962. The advantages of the NDI test are the following: the test is easy to perform, not time-consuming, and a very little volume of blood is necessary (0.