Impact of worklist selection on point-of-care ultrasound workflow - a quality improvement project.

Background: Research demonstrates that Point-of-care ultrasound (POCUS) improves clinical outcomes for patients. Improving clinician satisfaction with POCUS should promote utilization into everyday practice, leading to improved clinical outcomes. Despite this benefit, there are still barriers to use including POCUS workflow.

Subacromial Distal Clavicle Dislocation with Associated Scapular Spine Fracture: A Case Report.

Introduction: Inferior or subacromial dislocation of the distal clavicle is a rare entity. Previous reports of this injury pattern have largely been limited to Rockwood VI acromioclavicular joint (AC) dislocations, with the distal clavicle located in the subcoracoid position. Few case reports have been described with the inferior clavicle being located in the subacromial space, and these have all been previously associated with clavicle fractures.

Brief Report: Cystatin C Provides Substantially Higher Glomerular Filtration Rate Estimates Than Creatinine in a Subset of Black People With HIV on Current Antiretroviral Regimens.

Background: In African populations, estimated glomerular filtration rate by cystatin C (eGFRcys) is better aligned with gold-standard GFR measurements than eGFR by creatinine (eGFRcr). Moreover, eGFRcys is unaffected by the effects of antiretroviral therapy (ART) on tubular secretion and may thus provide better estimates of GFR in people with HIV on ART.

Setting: Observational cohort study of people of African ancestry living with suppressed HIV RNA on ART in London, United Kingdom.

Pre-Catheterization Computed Tomography Angiography Aids in the Selection of Ductus Arteriosus Stent Length for Ductal-Dependent Pulmonary Blood Flow.

PDA stenting is increasingly utilized for patients with ductal-dependent pulmonary blood flow. Predicting optimal stent length prior to and during the intervention remains a challenge. The utility of pre-catheterization computed tomography angiography (CTA) to predict stent length was evaluated.

Contraceptive use, prevalence and incidence of pregnancy and associated factors among women participating in a vaccine preparedness cohort study in Masaka, Uganda, a retrospective secondary analysis.

Background: HIV prevention trials usually require that women of childbearing potential use an effective method of contraception. This is because the effect of most investigational products on unborn babies is unknown. We assessed contraceptive use, prevalence and incidence of pregnancy and associated factors among women in a HIV vaccine preparedness study in Masaka, Uganda.

Predictors for noncompliant intravascular catheter insertion site dressings at a large academic center.

Using intravascular catheter dressing audit data, we evaluated factors associated with noncompliant dressing. Male sex and gauze dressing had a higher risk of noncompliant dressing; presence of one or more lumens infusing, central venous catheter, peripherally inserted central catheters line, implantable port and contact precautions were associated with a lower risk of noncompliant dressing.

Corrigendum to "Genetic Variants of Are Major Determinants of Kidney Failure in People of African Ancestry With HIV" [ Volume 7, Issue 4, April 2022, Pages 786-796].

[This corrects the article DOI: 10.1016/j.ekir.

Subjective cognitive complaints and future risk of dementia and cognitive impairment, which matters most.

Many older adults report subjective cognitive decline (SCD); however, the specific types of complaints most strongly associated with early disease detection remain unclear. This study examines which complaints from the Everyday Cognition Scales (ECog) are associated with progression from normal cognition to mild cognitive impairment (MCI)/dementia. 415 older adults were monitored annually for 5 years, on average.

Validity Evidence for Using Virtual, Interactive Patient Encounters to Teach and Assess Clinical Reasoning for First-Year Medical Students.

Purpose: Despite universal agreement on the importance of clinical reasoning skills, inadequate curricular attention to these skills remains a problem. To facilitate integration of clinical reasoning instruction and assessment into the preclerkship phase, the authors created a clinical reasoning curriculum using technology-enhanced patient simulations.

Method: In 2023, first-year medical students at Duke University School of Medicine were enrolled in a biomedical science course using diagnostic reasoning sessions and 16 virtual, interactive patient (VIP) encounters to teach and assess clinical reasoning.

The transcriptional regulator Lrp activates the expression of genes involved in the biosynthesis of tilimycin and tilivalline enterotoxins in .

The toxigenic strains secrete tilymicin and tilivalline enterotoxins, which cause antibiotic-associated hemorrhagic colitis. Both enterotoxins are non-ribosomal peptides synthesized by enzymes encoded in two divergent operons clustered in a pathogenicity island. The transcriptional regulator Lrp (eucine-responsive egulatory rotein) controls the expression of several bacterial genes involved in virulence.

Rural and metropolitan applicants' experiences of the admissions process for a provisional entry regional medical training pathway.

Objective: To explore the experiences and perceptions of rural and metropolitan applicants preparing for and completing all admission components for a provisional entry regional medical pathway.

Setting: Provisional entry regional medical pathway.

Participants: Provisional entry (school-leaver) applicants (N = 18) who completed a Multiple Mini-Interview (MMI).

RPA and Rad27 limit templated and inverted insertions at DNA breaks.

Formation of templated insertions at DNA double-strand breaks (DSBs) is very common in cancer cells. The mechanisms and enzymes regulating these events are largely unknown. Here, we investigated templated insertions in yeast at DSBs using amplicon sequencing across a repaired locus.

Developing nitrogen bioextraction economic value via off-bottom oyster aquaculture in the northwestern Gulf of Mexico.

Eutrophication remains a persistent water quality issue throughout much of the United States, leading to changes to ecosystem health in valuable coastal habitats. Oysters help to buffer against eutrophication by removing nitrogen from the water column by feeding on phytoplankton and other seston, a process referred to as "bioextraction". Recent legislation in Texas has allowed oysters to be grown off-bottom (suspended in cages).

Draft genome sequences of strains isolated from ocular surface of CD36-knockout mice (B6.129S1-/J) with keratitis.

Three strains were cultured from the eyes of CD36-knockout mice (B6.129S1-/J) with and without keratitis housed at a biomedical research institute. Bacteria were sequenced using Illumina MiSeq technology for subsequent phylogenetic characterization and identification of virulence factor genes conferring pathogenic potential.

Impact of polystyrene nanoplastics on physiology, nutrient uptake, and root system architecture of aeroponically grown citrus plants.

The widespread presence of plastic pollution has become a challenge for both aquatic and terrestrial plants. Notably, nanoplastics (NPs) have been found to enter the root tissues and translocate to different organs of plants; however, most previous studies were performed using crop or vegetable seedlings, and the extent NPs accumulation in fruit tree plants, particularly citrus, and their impacts remains unclear. This study was designed to fill this gap by determining the uptake and accumulation of green, fluorescent polystyrene nanoplastics (PS-NPs) of two different sizes (20 nm and 50 nm in diameter) in citrus rootstock ('US-942') in an aeroponic system and their impact on plant growth and physiological functions, nutrient uptake, and root system architectural and anatomical traits.

Bioorthogonal Activation of Deep Red Photoredox Catalysis Inducing Pyroptosis.

The revolutionary impact of photoredox catalytic processes has ignited novel avenues for exploration, empowering us to delve into nature in unprecedented ways and to pioneer innovative biotechnologies for therapy and diagnosis. However, integrating artificial photoredox catalysis into living systems presents significant challenges, primarily due to concerns over low targetability, low compatibility with complex biological environments, and the safety risks associated with photocatalyst toxicity. To address these challenges, herein, we present a novel bioorthogonally activatable photoredox catalysis approach.

Sustained impacts of the COVID-19 pandemic on medical student learning and well-being in rural Australia: findings from a repeated national multicentre survey.

Objective: The impact of COVID-19 on medical students has predominantly been assessed by one-off survey studies at the pandemic onset. This national study investigated the sustained impacts of the COVID-19 pandemic on medical students' rural clinical placement learning and well-being.

Design: Repeated cross-sectional survey design.

Slowly getting there: a review of country experience on estimating emissions and removals from forest degradation.

Estimating emissions and removals from forest degradation is important, yet challenging, for many countries. This paper reports results from analysis of country reporting (to the United Nations Framework Convention on Climate Change and also to several climate finance initiatives) and key take-aways from a south-south exchange workshop among 17 countries with forest mitigation programmes. During the workshop discussions it became clear that, where forest degradation is a major source of emissions, governments want to include it when reporting on their mitigation efforts.

Indirect Costs of Alzheimer's Disease: Unpaid Caregiver Burden and Patient Productivity Loss.

Objectives: The direct medical costs associated with Alzheimer's disease (AD) in the United States have been estimated to be over $360 billion USD, but this value does not reflect the substantial financial burden on unpaid caregivers and society. We estimated the economic burden of unpaid caregivers and patient productivity loss because of AD across all disease severity stages to better understand the indirect impacts of AD.

Methods: We performed a narrative literature review to identify estimates of unpaid caregiver burden and market productivity loss.

Influences of cerium oxide nanoparticles and salinity on common bean (Phaseolus vulgaris) growth, physiology, and root system architectural and anatomical traits.

Engineered nanoparticles (ENPs) have emerged as global pollutants due to their extensive use across various industries, raising particular concerns in agricultural settings. This study addresses the understudied interactions between ENPs, specifically cerium oxide nanoparticles (CeO₂NPs), and sodium chloride (NaCl) in agricultural crops, within the context of widespread soil salinization. 'Pinto' common bean seedlings were cultivated in sand-filled pots under greenhouse conditions, following a completely randomized experimental design for one month.