Potential of cyclodextrin-based formulations of essential oils in the control of the date moth (Pyralidae).

Recently essential oils (EOs) encapsulation is experiencing growing applications in agricultural and agri-food sector. Encapsulation is reported as safe environmental technology leading to a reduction of conventional insecticides use. This study concerns the assessment of fumigant toxicity and persistence of EO encapsulated in two cyclodextrins β-CD and HP-β-CD against larvae of the date moth, The retention capacity, encapsulation efficacy, loading capacity and release behavior of the two inclusion complexes were investigated.

Hydrophobic binary mixtures containing amphotericin B as lipophilic solutions for the treatment of cutaneous leishmaniasis.

Cutaneous leishmaniasis, caused by Leishmania parasites, requires treatments with fewer side effects than those currently available. The development of a topical solution based on amphotericin B (AmB) was pursued. The considerable interest in deep eutectic solvents (DESs) and their remarkable advantages inspired the search for a suitable hydrophobic excipient.

Investigation of Doehlert matrix conception in novel intrinsically conducting polymers based on selenium nanoparticles for wastewater treatment: Synthesis, characterization, kinetic and chemometric study.

The synthesis of robust intrinsically conducting polymers (ICPs) based on nanoparticles is becoming increasingly attractive to the research community due to the unique properties of these nanocomposites. Indeed, as organic semiconductors, ICPs combine both polymer and metal properties in a single structure. This study presents an innovative approach in which the Doehlert Matrix (DM) is applied to a novel ICP nanocomposite based on polyaniline (Pani) coupled with selenium (Se) loaded mesoporous titania (TiO) for wastewater treatment by photocatalysis.

A High-Throughput Experimental Approach to Screening Gas Sorption by Liquids and Solids.

High-precision measurement of gas uptake from single or mixed feeds in solid and liquid sorbents traditionally requires time-consuming experimental procedures and/or complex and costly equipment. A simple and cost-effective headspace gas chromatography (HS-GC) approach for the fast, universal experimental screening of sorbents for gas uptake and/or determination of their real gas separation selectivity has been developed and is demonstrated for pressures up to 2500 mbar and temperatures above 30 °C. This method allows screening of solids and both volatile and nonvolatile liquid materials, physisorbents, and chemisorbents using both single and mixed permanent gases that can include CO, CH, H, and NH, for gas uptakes as low as 0.

Cyclodextrins permeabilize DPPC liposome membranes: a focus on cholesterol content, cyclodextrin type, and concentration.

Cyclodextrins (CDs) are known for their ability to extract lipid components from synthetic and biological membranes and therefore to induce an increase of membrane permeability. However, the effect of cholesterol (CHOL) content in the membrane on the CD permeabilizing effect was not considered yet. Given that an increase in CHOL content reduces the membrane permeability, the aim of this work was to reveal how CHOL would modulate the CDs effect on the membrane.

Liquid Structure Scenario of the Archetypal Supramolecular Deep Eutectic Solvent: Heptakis(2,6-di--methyl)-β-cyclodextrin/levulinic Acid.

The concept of supramolecular solvents has been recently introduced, and the extended liquid-state window accessible for mixtures of functionalized cyclodextrins (CDs) with hydrogen bond (HB) donor species, e.g., levulinic acid, led to the debut of supramolecular deep eutectic solvents (SUPRA-DES).

Encapsulation of Rosmarinus officinalis essential oil and of its main components in cyclodextrin: application to the control of the date moth Ectomyelois ceratoniae (Pyralidae).

Background: Synthetic insecticides are the most useful tools for preventing losses caused by insect pest's infestation during storage. However, the use of pesticides should be limited because of the development of insect resistance and their adverse effects on human health and environment. In the last decades, natural insecticidal products, principally essential oils (EOs) and their active components, exhibited potential alternatives for pest control.

Cyclodextrin-based Schiff base pro-fragrances: Synthesis and release studies.

A simple method for the preparation of β-cyclodextrin derivatives containing covalently bonded aldehydes via an imine bond was developed and used to prepare a series of derivatives from 6-amino-6-deoxy-β-cyclodextrin and the following volatile aldehydes - cinnamaldehyde, cyclamen aldehyde, lilial, benzaldehyde, anisaldehyde, vanillin, hexanal, heptanal, citral, and 5-methylfurfural. Subsequently, the rate of release of the volatile compound from selected pro-fragrances, as a function of the environment (solvent, pH), was studied by H NMR spectroscopy (for benzaldehyde) and static headspace-gas chromatography (for benzaldehyde, heptanal, and 5-methylfurfural). The aldehyde release rate from the imine was shown to depend substantially on the pH from the solution and the air humidity from the solid state.

Chemical Composition, Antioxidant and Anti-Inflammatory Activities of Clary Sage and Coriander Essential Oils Produced on Polluted and Amended Soils-Phytomanagement Approach.

The potential of essential oils (EO), distilled from two aromatic plants-clary sage ( L.) and coriander ( L.)-in view of applications as natural therapeutic agents was evaluated .

Cyclodextrin-based supramolecular low melting mixtures: efficient absorbents for volatile organic compounds abatement.

Cyclodextrins (CDs) and deep eutectic solvents (DESs) are emerging absorbent materials for the removal of volatile organic compounds (VOCs). In this study, we have used combination of modified CDs and levulinic acid to form four DESs analogs, referred to as supramolecular low-melting mixtures (LMMs), to study their absorption characteristics towards five VOCs, namely acetaldehyde, butanone, dichloromethane, thiophene, and toluene. The supramolecular LMMs showed up to 250-fold reduction in the vapor-liquid partition coefficients compared to water.

Cyclodextrins: from solute to solvent.

A supramolecular solvent based on cyclodextrin (CD) is presented here for the first time. Indeed, a low melting mixture was obtained by mixing levulinic acid and a CD derivative, which retained its inclusion ability in the resulting solvent. This new system gives rise to a new family of solvents that could be called SUPRADES (supramolecular deep eutectic solvents).

Drug-in-hydroxypropyl-β-cyclodextrin-in-lipoid S100/cholesterol liposomes: Effect of the characteristics of essential oil components on their encapsulation and release.

Drug-in-cyclodextrin-in-liposome (DCL) represents a very promising approach for preserving essential oil (EO) components, thereby extending their shelf life and activity. In this study, we examined the effect of chemical structure, octanol/water partition coefficient (log P), and Henry's law constant (H) on the encapsulation and the release of monoterpenes (eucalyptol, pulegone, terpineol, and thymol) and phenylpropenes (estragole and isoeugenol) from DCLs. Hydroxypropyl-β-cyclodextrin/EO component (HP-β-CD/EO component) inclusion complexes were prepared in aqueous solution and loaded into liposomes by the ethanol injection method.

Antibacterial activity of free or encapsulated selected phenylpropanoids against Escherichia coli and Staphylococcus epidermidis.

Aims: Antibacterial activities of phenylpropenes (PPs) (eugenol, isoeugenol, estragole and trans-anethole) and hydroxycinnamic acids (HCAs) (p-coumaric, caffeic and ferulic acids) were assessed against Escherichia coli and Staphylococcus epidermidis. Effect of cyclodextrin and liposome encapsulation on the PPs activity was also evaluated.

Methods And Results: All PPs inhibited the bacterial growth in the hundred micromolar range, while HCAs did not, as determined by broth macrodilution.

Cyclodextrin-membrane interaction in drug delivery and membrane structure maintenance.

Cyclodextrins (CDs) are cyclic oligosaccharides able to improve drug water solubility and stability by forming CD/drug inclusion complexes. To further increase drug entrapment and delay its release, the CD/drug inclusion complex can be embedded in the aqueous phase of a liposome, a lipid vesicle composed of phospholipid bilayer surrounding an aqueous compartment. The resulting carrier is known as drug-in-cyclodextrin-in-liposome (DCL) system.

New findings on the incorporation of essential oil components into liposomes composed of lipoid S100 and cholesterol.

The encapsulation of essential oil components into liposomes was demonstrated to improve their solubility and chemical stability. In this study, we investigated the effect of chemical structure, Henry's law constant (H), and aqueous solubility of essential oil components on their liposomal encapsulation. Estragole, eucalyptol, isoeugenol, pulegone, terpineol, and thymol were encapsulated in lipoid S100-liposomes using the ethanol injection method.

Post-harvest management control of Ectomyelois ceratoniae (Zeller) (Lepidoptera: Pyralidae): new insights through essential oil encapsulation in cyclodextrin.

Background: Essential oils are reported to be bio-insecticides. However, problems related to their volatility, oxidation and poor water solubility need to be solved before they can be considered as replacement pest control methods. Thus, an appropriate formulation is needed for commercial use.

Effect of cyclodextrin and cosolvent on the solubility and antioxidant activity of caffeic acid.

Caffeic acid is a natural phenylpropanoid that exhibits various health benefits. However, it suffers from a poor aqueous solubility limiting its application. This drawback could be overcome by complexation in cyclodextrins (CD) or cosolvency.

Hydroxypropyl-ß-cyclodextrin as a membrane protectant during freeze-drying of hydrogenated and non-hydrogenated liposomes and molecule-in-cyclodextrin-in- liposomes: Application to trans-anethole.

The effect of hydrogenation of phospholipids on the characteristics of freeze-dried liposomes was investigated using hydroxypropyl-ß-cyclodextrin (HP-ß-CD) as membrane protectant. The ethanol-injection method was applied to prepare liposomes using hydrogenated (Phospholopion-90H and 80H) and non-hydrogenated phospholipids (Lipoid-S100) in combination with cholesterol. Various liposomal formulations were tested: conventional liposomes (CL) and HP-ß-CD-loaded liposomes (CDL).

Characterization of Cyclodextrin/Volatile Inclusion Complexes: A Review.

Cyclodextrins (CDs) are a family of cyclic oligosaccharides that constitute one of the most widely used molecular hosts in supramolecular chemistry. Encapsulation in the hydrophobic cavity of CDs positively affects the physical and chemical characteristics of the guests upon the formation of inclusion complexes. Such a property is interestingly employed to retain volatile guests and reduce their volatility.

First evaluation of drug-in-cyclodextrin-in-liposomes as an encapsulating system for nerolidol.

Nerolidol, a naturally occurring sesquiterpene with antimicrobial activities, is a promising candidate as a natural alternative for synthetic preservatives in food. However, its application is limited by low aqueous solubility and stability. In this study, conventional liposomes and drug-in-cyclodextrin-in-liposomes (DCLs) were evaluated for the first time as encapsulating materials for nerolidol.

New nanoparticles obtained by co-assembly of amphiphilic cyclodextrins and nonlamellar single-chain lipids: Preparation and characterization.

This work aimed at preparing new nanoscale assemblies based on an amphiphilic bio-esterified β-cyclodextrin (β-CD), substituted at the secondary face with n-decanoic fatty acid chains (β-CD-C), and monoolein (MO) as new carriers for parenteral drug delivery. Stable binary (β-CD-C/MO) and ternary (β-CD-C/MO/stabilizer) nanoscale assemblies close to 100nm in size were successfully prepared in water by the solvent displacement method. The generated nanoparticles were fully characterized by dynamic light scattering, transmission electron microscopy, small-angle X-ray scattering, residual solvent analysis, complement activation and the contribution of each formulation parameter was determined by principal component analysis.

Nootkatone encapsulation by cyclodextrins: Effect on water solubility and photostability.

Nootkatone (NO) is a sesquiterpenoid volatile flavor, used in foods, cosmetics and pharmaceuticals, possessing also insect repellent activity. Its application is limited because of its low aqueous solubility and stability; this could be resolved by encapsulation in cyclodextrins (CDs). This study evaluated the encapsulation of NO by CDs using phase solubility studies, Isothermal Titration Calorimetry, Nuclear Magnetic Resonance spectroscopy and molecular modeling.

The effect of cyclodextrin complexation on the solubility and photostability of nerolidol as pure compound and as main constituent of cabreuva essential oil.

Nerolidol (Ner), a major component of many plant essential oils, is known for its various biological properties. However, the low solubility of Ner in water and its susceptibility to degradation limit its application. The aim of our study was to improve the solubility and photostability of Ner through its encapsulation in different cyclodextrins (CDs).