Evaluation of the efficacy, in terms of pain and disability, of a functional restoration programme in patients with chronic low back pain according to the presence of Modic 1 discopathy.

Objectives: Modic type 1 disc disease (MD1) appears to be related to severe Chronic Low Back Pain (CLBP). Functional Restoration Programmes (FRP) recommended in CLBP may not be suitable for patients with MD1. The main objective was to evaluate the effectiveness of a FRP, on the perceived incapacity and the pain intensity, in patients with non-specific CLBP according to the presence of MD1.

Comprehensive personalized ankle joint shape analysis of children with cerebral palsy from pediatric MRI.

Cerebral palsy, a common physical disability in childhood, often causes abnormal patterns of movement and posture. To better understand the pathology and improve rehabilitation of patients, a comprehensive bone shape analysis approach is proposed in this article. First, a group analysis is performed on a clinical MRI dataset using two state-of-the-art shape analysis methods: ShapeWorks and a voxel-based method relying on Advanced Normalization Tools (ANTs) registration.

Impact of Anti PD-1 Immunotherapy on HIV Reservoir and Anti-Viral Immune Responses in People Living with HIV and Cancer.

The role of immune checkpoints (ICPs) in both anti-HIV T cell exhaustion and HIV reservoir persistence, has suggested that an HIV cure therapeutic strategy could involve ICP blockade. We studied the impact of anti-PD-1 therapy on HIV reservoirs and anti-viral immune responses in people living with HIV and treated for cancer. At several timepoints, we monitored CD4 cell counts, plasma HIV-RNA, cell associated (CA) HIV-DNA, EBV, CMV, HBV, HCV, and HHV-8 viral loads, activation markers, ICP expression and virus-specific T cells.

Validation of the General Health Questionnaire 12 for assessing psychological distress in patients with chronic low back pain.

Background: The General Health Questionnaire 12 (GHQ-12) is a short easy-to-use scale to assess psychological distress. The GHQ-12 has not been validated for assessing psychological distress in patients with chronic low back pain (LBP).

Objective: To investigate the psychometric properties of the GHQ-12 in patients with chronic LBP.

2020 French recommendations on the management of septic arthritis in an adult native joint.

Septic arthritis (SA) in an adult native joint is a rare condition but a diagnostic emergency due to the morbidity and mortality and the functional risk related to structural damage. Current management varies and the recommendations available are dated. The French Rheumatology Society (SFR) Bone and Joint Infection Working Group, together with the French Language Infectious Diseases Society (SPILF) and the French Orthopaedic and Trauma Surgery Society (SOFCOT) have worked according to the HAS methodology to devise clinical practice recommendations to diagnose and treat SA in an adult native joint.

A homozygous mutation underlies a familial case of non-syndromic primary ovarian insufficiency.

Primary Ovarian Insufficiency (POI) affects ~1% of women under forty. Exome sequencing of two Finnish sisters with non-syndromic POI revealed a homozygous mutation in leading to a truncated protein (p.Gln1701*).

Visceral obesity and chronic pain: effect of a 4-week rehabilitation program on adipokines and insulin resistance.

Obesity and chronic pain are two major diseases of the 21th century. Our principal objective was to investigate the effects of a 4-week rehabilitation program on adiponectin and leptin concentrations, and insulin resistance, in patients with abdominal obesity and chronic pain syndrome. Our secondary objectives were to investigate the effects of this program on pain, body mass index (BMI), waist circumference and maximal oxygen consumption (VO) and to compare changes in VO between patients with or without insulin resistance.

BMP15 "knockout-like" effect in familial premature ovarian insufficiency with persistent ovarian reserve.

Premature ovarian insufficiency (POI) affects 1% to 2% of women under 40 years. Bone morphogenetic protein 15 (BMP15) variants have been described in POI. We studied a family with 2 sisters compound heterozygous for deletions in the BMP15 gene on chromosome Xp11.

Ovarian-like differentiation in eutopic and ectopic endometrioses with aberrant FSH receptor, INSL3 and GATA4/6 expression.

Endometriosis, the hormone-dependent extrauterine dissemination of endometrial tissue outside the uterus, affects 5-15% of women of reproductive age. Pathogenesis remains poorly understood as well as the estrogen production by endometriotic tissue yielding autocrine growth. Estrogens (E2) are normally produced by the ovaries.

Claudin-6 and Occludin Natural Variants Found in a Patient Highly Exposed but Not Infected with Hepatitis C Virus (HCV) Do Not Confer HCV Resistance In Vitro.

The clinical course of Hepatitis C Virus (HCV) infection is highly variable between infected individual hosts: up to 80% of acutely HCV infected patients develop a chronic infection while 20% clear infection spontaneously. Spontaneous clearance of HCV infection can be predicted by several factors, including symptomatic acute infection, favorable IFNL3 polymorphisms and gender. In our study, we explored the possibility that variants in HCV cell entry factors might be involved in resistance to HCV infection.

Claudin-1 gene variants and susceptibility to hepatitis C infection in HIV-1 infected intravenous drug users (an ANRS case-control study).

Hepatitis C virus (HCV) seroprevalence is highly diverse among human immunodeficiency virus-1 (HIV-1) infected patients, ranging between 10% of HIV-1 infected homo-bisexuel men, to >92% in patients infected with HIV-1 who acquired HIV-1 through intravenous drug use. Thus, being HCV-free while having acquired HIV-1 via intravenous drug use is a rare situation. Claudin-1 is a protein involved in intracellular tight-junctions and has been identified as a major cellular co-receptor for HCV infection.

Focal adhesion kinase is involved in rabies virus infection through its interaction with viral phosphoprotein P.

Unlabelled: The rabies virus (RABV) phosphoprotein P is a multifunctional protein: it plays an essential role in viral transcription and replication, and in addition, RABV P has been identified as an interferon antagonist. Here, a yeast two-hybrid screen revealed that RABV P interacts with the focal adhesion kinase (FAK). The binding involved the 106-to-131 domain, corresponding to the dimerization domain of P and the C-terminal domain of FAK containing the proline-rich domains PRR2 and PRR3.

Kinesiophobia negatively influences recovery of joint function following total knee arthroplasty.

Background: The influence of kinesiophobia on disability in patients with knee osteoarthritis is known, but its influence on functional recovery after total knee arthroplasty remains unexplored.

Aims: To assess the influence of kinesiophobia on functional recovery following total knee arthroplasty (TKA) in patients with knee osteoarthritis and to investigate if kinesiophobia was more common in obese patients than in non-obese patients.

Design: Cohort study.

[Work-related musculoskeletal disorders: priority to prevention and coordination of the interventions].

Upper-limb musculoskeletal disorders (UL-MSDs) are painful conditions related to the overuse of periarticular soft tissues. The main UL-MSDs are rotator cuff tendinopathy, epicondylalgia, carpal tunnel syndrome and non-specific pain UL-MSDs are multifactorial disorders associated with individual and occupational (biomechanical, psychosocial and factors related to work organization) risk factors. Treatments are based on a global assessment of the clinical, social and occupational situations in order to identify cases of good prognosis and those, ess frequent, at high risk of prolonged work disability.

VO₂max in patients with chronic pain: the effect of a 4-week rehabilitation program.

Background: In patients with chronic pain, aerobic deconditioning can explain part of observed disability and disadvantage. The objective of the present study was to assess the change in VO₂max after a four-week exercise rehabilitation programme in this population.

Methods: In a prospective study, 121 patients underwent a cycle ergometer exercise tolerance test with VO₂max measurement before and after a four-week exercise rehabilitation programme (which included aerobic training, muscle strengthening, occupational therapy and stretching).

Validation of a French version of Roland-Morris questionnaire in chronic low back pain patients.

Objective: To validate a French version of the Roland-Morris Disability Questionnaire (RMDQ) in patients with chronic low back pain (LBP).

Material And Methods: Fifty-eight patients due to participate in a functional rehabilitation programme for chronic low back pain were included prospectively. The RMDQ, the Quebec Back Pain Disability Scale (QBPDS) and the "daily activities" subscale of the Dallas Pain Questionnaire (DPQ) were administered.

Care related pain and functional restoration for chronic low back pain: a prospective study.

Objective: To assess care related pain during a program of functional restoration for chronic low back pain.

Patients And Methods: Chronic low back pain patients were prospectively included in a program of functional restoration. Low back pain was recorded before and after each morning and afternoon sessions, all over the program of functional restoration, for equivalence study.

[The free gracilis muscle flap in the foot and ankle reconstructive surgery].

Subject: The distal third of the leg, ankle and foot is an anatomical region where reconstructive surgery is difficult and many flaps are described. The authors describe their own experience in the reconstruction of this anatomical region using the gracilis muscle free flap.

Methods: From January 2009 to April 2012, the authors operated 32 patients for reconstructive surgery of the distal third of the leg, ankle or foot using a free gracilis muscle flap.

[Donor site morbidity after free gracilis muscle flap. Report of 32 cases].

Background: Coverage of tissue defects of the lower limbs is a complex problem. Free gracilis muscle flap is a reliable surgical technique and the morbidity of its donor site is considered as minimal. Our retrospective study involved all patients who underwent a free gracilis muscle flap in a reconstructive surgery of the lower limb.

VO(2)max in patients with chronic pain: comparative analysis with objective and subjective tests of disability.

Objectives: To establish the level of maximal aerobic capacity in patients with chronic pain of different etiologies and to compare these results with different parameters of disability.

Patients And Methods: A cycloergometer exercise test with VO(2)max measurement, fatigue assessment and objective and subjective disability parameter testing was performed on 155 patients (mean age 42.1 ± 9.

Identification of a new phospholipase D in Carica papaya latex.

Phospholipase D (PLD) is a lipolytic enzyme involved in signal transduction, vesicle trafficking and membrane metabolism. It catalyzes the hydrolysis and transphosphatidylation of glycerophospholipids at the terminal phosphodiester bond. The presence of a PLD in the latex of Carica papaya (CpPLD1) was demonstrated by transphosphatidylation of phosphatidylcholine (PtdCho) in the presence of 2% ethanol.