Generalizing multipartite concentratable entanglement for practical applications: mixed, qudit and optical states.

The controlled SWAP test for detecting and quantifying entanglement applied to pure qubit states is robust to small errors in the states and efficient for large multi-qubit states (Foulds . 2021 . , 035002 (doi:10.

Behaviors and Actions of the Strength and Conditioning Coach in Fostering a Positive Coach-Athlete Relationship.

Carson, F, Blakey, M, Foulds, SJ, Hinck, K, and Hoffmann, SM. Behaviors and actions of the strength and conditioning coach in fostering a positive coach-athlete relationship. J Strength Cond Res 36(11): 3256-3263, 2022-A number of models have been developed to explain the various factors that affect coach-athlete interactions; however, they have had limited application to strength and conditioning (S&C).

The Coach-Athlete Relationship in Strength and Conditioning: High Performance Athletes' Perceptions.

The primary purpose of this study was to investigate high performance athlete perceptions of strength and conditioning coaches, specifically, (1) their character traits, (2) the effective behaviours that display these traits, and (3) how these relationships were fostered. Using the 3+1 C's model of coach-athlete relationships as a framework (Jowett, 2007), 12 semi-structured interviews were conducted with high performance athletes (six female; six male) representing a variety of sports (i.e.

Flood-related contamination in catchments affected by historical metal mining: an unexpected and emerging hazard of climate change.

Floods in catchments affected by historical metal mining result in the remobilisation of large quantities of contaminated sediment from floodplain soils and old mine workings. This poses a significant threat to agricultural production and is preventing many European river catchments achieving a 'good chemical and ecological status', as demanded by the Water Framework Directive. Analysis of overbank sediment following widespread flooding in west Wales in June 2012 showed that flood sediments were contaminated above guideline pollution thresholds, in some samples by a factor of 82.

Neutrophil activation and hyperamylasaemia after endoscopic retrograde cholangiopancreatography: potential role for the leukocyte in the pathogenesis of acute pancreatitis.

Background And Study Aims: Hyperamylasaemia occurs in up to 60% of patients following endoscopic retrograde cholangiopancreatography (ERCP), and in a small proportion of patients (1-5%) acute pancreatitis may develop. We evaluated the role of the neutrophil in post-ERCP hyperamylasaemia and acute pancreatitis by measuring circulating CD11b adhesion receptor expression--an indicator of leukocyte activation.

Patients And Methods: A total of 43 patients undergoing elective ERCP were studied.

Transcription factor NF kappa B expression and postsurgical organ dysfunction.

Objective: To examine the role of neutrophil NF kappa B activation in organ dysfunction after major surgery.

Summary Background Data: NF kappa B is a transcription factor involved in the signal transduction of many stimuli that may participate in the pathogenesis of sepsis and resultant multiple organ dysfunction syndrome (MODS). It may therefore be a potential target for modulation in the reduction of postsurgical MODS.

Visceral ischemia and neutrophil activation in sepsis and organ dysfunction.

Background: It has previously been shown that a rise in intraoperative neutrophil CD11b expression during supracoeliac cross-clamping is a marker for subsequent development of postoperative organ dysfunction. Prolonged visceral ischemia and increased aneurysm extent are associated with higher risks of morbidity and mortality after TAAA repair. This study investigates the relationship between visceral ischemia and neutrophil activation in sepsis and organ dysfunction following visceral reperfusion.

Novel flow cytometric method for quantifying nuclear binding of the transcription factor nuclear factor kappa B in unseparated human monocytes and polymorphonuclear cells.

The transcription factor nuclear factor kappa B (NF kappa B) regulates the production of a number of pro-inflammatory mediators involved in polymorphonuclear and mononuclear cell activation. Measurement of NF kappa B DNA binding is used as an estimate of cellular activation and is usually measured by the DNA mobility shift assay. Results from the mobility shift assay can be difficult to quantify and do not allow discrimination of activity in different populations of cells in whole blood without prior separation.

Endotoxin related early neutrophil activation is associated with outcome after thoracoabdominal aortic aneurysm repair.

Background: Thoracoabdominal aortic aneurysm (TAAA) repair is associated with high mortality rates, especially in patients who develop postoperative renal and pulmonary impairment. Organ damage during TAAA repair may be mediated by activated polymorphonuclear neutrophils (PMNs) during a systemic inflammatory response. The association between intraoperative neutrophil activation and postoperative outcome was studied after TAAA surgery.

Surgery and the release of a neutrophil Fc gamma receptor.

Background: The fact that the incidence and mortality from postsurgical sepsis have remained unchanged over the past 15 years raises the possibility that some patients possess an idiosyncratic predisposition to the development of a postoperative sepsis response. Genetic polymorphisms of the neutrophil receptor for immunoglobulin G, CD16, are known, and their inheritance is associated with functional differences in neutrophil phagocytosis. The present studies were designed to provide preliminary data on the effects of surgery on the level of expression of CD16 and its metabolism preparatory to detailed examination of the relationship of these polymorphisms to sepsis responses.

Swainsonine, a glycosylation inhibitor, enhances both lymphocyte efficacy and tumour susceptibility in LAK and NK cytotoxicity.

Swainsonine (SW) inhibits the formation of N-linked complex oligosaccharides and has previously been shown to inhibit experimental metastasis in nude mice models. The present studies with human effector cells have shown that SW enhanced both lymphokine activated killer cell (LAK) and natural killer (NK) cytotoxicity in standard 51Cr-release assays. SW also increased the susceptibility of human K562 and Colo 320 target cells to NK and LAK cytotoxicity.

Glutathione S-transferase Mu phenotype in patients with familial adenomatous polyposis and in unaffected controls.

Patients with familial adenomatous polyposis (FAP) are at high risk for duodenal tumors, the distribution of which suggests that bile is important in their development. Studies of the bile of FAP patients suggest that it contains an excess of active carcinogens. Defective hepatic metabolism of carcinogens might account for these findings.

Expression of a suppressive p15E-related epitope in colorectal and gastric cancer.

mRNA for the suppressive epitope of p15E was found to be present in 24 of 30 samples of human colorectal cancer and in all four specimens of gastric cancer. mRNA for p15E was seldom seen in nonmalignant colonic or gastric mucosa but, when present, was associated with inflammatory or pre-malignant conditions of the digestive tract. Synthetic peptides derived from the conserved p15E sequence were found to suppress some aspects of the immune response implicated in anti-tumour activity.

Polymorphonuclear leukocyte activation. An early marker of the postsurgical sepsis response.

It has been suggested that major surgery induces polymorphonuclear leukocyte (PMNL) dysfunction, which exposes patients to the development of sepsis. Conversely, the sepsis response and multisystem organ failure in patients after surgery is thought to be mediated by activated PMNLs. In a preliminary attempt to investigate this paradox, we studied functional (hydrogen peroxide production) and phenotypic (the adhesion/complement receptor CD11b) markers of PMNL activation in 28 patients undergoing elective major resectional surgery; 11 (39%) of these patients developed postoperative sepsis (the septic group).

Changes in major histocompatibility complex class II expression in monocytes and T cells of patients developing infection after surgery.

Expression of class II major histocompatibility complex (MHC) on monocytes is a prerequisite for effective antigen presentation and processing, an important component of the immune response to infection. It has been reported that the level of monocyte class II expression may identify patients who go on to develop infective complications following trauma. In the present study, flow cytometry was used to measure MHC class II (human leucocyte antigen (HLA)-DR) expression on circulating monocytes and T cells in 36 patients undergoing elective major resectional surgery, of whom 12 developed septic complications.

The use of Fab' fragments in a screening method for the detection of human anti-tumor monoclonal antibodies.

The use of immunoperoxidase staining methods to detect human monoclonal antibodies that react with frozen tissue sections of human tumors is limited due to endogenous immunoglobulin present in the sections. The endogenous immunoglobulin produces a significant background staining which makes the detection of a specific reaction difficult and unreliable. A method of incubating the sections with papain fragments (Fab') of goat anti-human immunoglobulin was evaluated.