Genetic polymorphisms influencing antihypertensive drug responses.

Hypertension is a major contributor to cardiovascular disease and its associated morbidity and mortality. The low efficacy observed with some anti-hypertensive therapies has been attributed partly to inter-individual genetic variability. This paper reviews the major findings regarding these genetic variabilities that modulate responses to anti-hypertensive therapies such as angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), diuretics, calcium channel blockers (CCBs) and β-adrenoceptor blockers.

Growth modification of the mandible with ultrasound in baboons: a preliminary report.

Introduction: Growth modification for patients with skeletal Class II malocclusions due to mandibular deficiency is controversial. Low-intensity pulsed ultrasound (LIPUS) can modify mandibular growth in growing rabbits. Before applying this treatment to humans, we must study the effect on mandibular growth in higher animal models.