Publications by authors named "Fotios N Tsitsos"
Article Synopsis
- Focused ultrasound (FUS) combined with microbubbles shows potential for enhancing drug delivery across the blood-brain barrier (BBB) in Alzheimer's disease, but current methods are limited by their reliance on MRI facilities or invasive procedures.
- A pilot study evaluated a new portable system, neuronavigation-guided FUS (NgFUS), in six mild to moderate Alzheimer’s patients, using real-time mapping of microbubble activity to ensure safety and efficacy during treatment.
- Results indicated that BBB opening was achieved in 5 out of 6 subjects, with significant correlations between cavitation dose, BBB opening volume, and increased levels of Alzheimer’s biomarkers, demonstrating the system's capability for real-time monitoring and safety in outpatient settings.
Article Synopsis
- Focused ultrasound (FUS) combined with microbubbles shows potential for opening the blood-brain barrier (BBB) to improve drug delivery in Alzheimer's disease, but current methods are limited to MRI-equipped settings or invasive implants.
- A pilot study involving 6 mild to moderate AD patients tested a new portable, non-invasive NgFUS system that monitored real-time microbubble activity to confirm safety and effectiveness during a single treatment session.
- The results indicated that BBB opening was successfully achieved in 5 out of 6 patients, with significant correlations observed between microbubble activity and BBB opening volume, alongside increases in Alzheimer-related biomarkers in the blood, suggesting effective drug delivery methods can emerge from this technology.
