Improving the Run-Time of Space-Efficient n-Gram Data Structures Using Apache Spark.

Storing information in memory efficiently is one of the most significant challenges in computer science. The two main factors that consist an efficient data structure is the reduction of space and time consumption. There is a plethora of different tools able to reduce the run-time of a process, and Apache Spark is one of these; it is a computing framework that is using clusters to execute a process.

Genome-based therapeutic interventions for β-type hemoglobinopathies.

For decades, various strategies have been proposed to solve the enigma of hemoglobinopathies, especially severe cases. However, most of them seem to be lagging in terms of effectiveness and safety. So far, the most prevalent and promising treatment options for patients with β-types hemoglobinopathies, among others, predominantly include drug treatment and gene therapy.

Documentation of clinically relevant genomic biomarker allele frequencies in the next-generation FINDbase worldwide database.

FINDbase (http://www.findbase.org) is a comprehensive data resource recording the prevalence of clinically relevant genomic variants in various populations worldwide, such as pathogenic variants underlying genetic disorders as well as pharmacogenomic biomarkers that can guide drug treatment.