Apolipoprotein E and paraoxonase 1 polymorphisms are associated with lower serum thyroid hormones in postmenopausal women.

Objective: Autoimmune thyroiditis and overt or subclinical hypothyroidism have been associated with increased prevalence of cardiovascular disease (CVD).

Design: Cross-sectional investigation of the association between gene polymorphisms related to CVD with thyroid function and autoimmunity.

Patients: In total 84 healthy postmenopausal women aged 49-69 years.

Once-yearly zoledronic acid in the prevention of osteoporotic bone fractures in postmenopausal women.

Zoledronic acid is a nitrogen-containing, third-generation bisphosphonate that has recently been approved for the treatment of postmenopausal osteoporosis as an annual intravenous infusion. Zoledronic acid is an antiresorptive agent which has a high affinity for mineralized bone and especially for sites of high bone turnover. Zoledronic acid is excreted by the kidney without further metabolism.