Preliminary use of linear discriminant function to predict success or failure of kidney transplant.

Adenylate kinase (AK) activity appears in serum or in urine as a result of tissue destruction. The serum and urine AK activity are normally very low (as previously reported). These studies were carried out to determine the usefulness of measuring the appearance of urinary AK activity in the detection of renal transplant crisis.

Respiratory drugs influence lung mucociliary clearance in central and peripheral ciliated airways.

Radiolabelling of mucus and gamma-camera imaging techniques were utilized to differentiate mucociliary function in large central and small peripheral bronchi of man. Lung mucus clearance was analyzed for the entire right lung field and a peripheral region, which was representative of mucus clearance from airways distal to lobar bronchi. On control days, healthy subjects breathed monodisperse particles, average size 4.

Synchronization of activity rhythms with the tide in a saltmarsh collembolan Anurida maritima.

On a marine saltmarsh, the intertidal collembolan Anurida maritima (Guérin) has a well-defined tidal rhythm of activity on the mud surface between submerging tides: a large proportion of the individuals emerge from their underground refuges shortly after the retreat of the tide, forage there for a few hours, and retire underground at least 1 h before the return of the tide. This activity rhythm has a period of about 12.4 h and it persists in the field during sequences of non-submerging tides and in the laboratory away from the tides in constant light.

Resection of abdominal aortic aneurysm in the presence of horseshoe kidney.

We report four cases of abdominal aortic aneurysm associated with horseshoe kidney. These cases illustrate the factors that determine the ease of resection in this situation: whether the isthmus of the kidney is parenchymatous or thin and fibrous; the presence or absence of anomalous renal arteries; and the origin of the arterial supply of the renal isthmus. Although the technical challenges involved in aneurysm resection in the presence of horseshoe kidney are significant, these cases illustrate that standard resection and replacement of the aneurysm with a prosthetic graft usually should be possible.

Affinity labeling of the active site of Escherichia coli glutamine synthetase by 5'-p-fluorosulfonylbenzoyladenosine.

The interaction of Escherichia coli glutamine synthetase with the adenosine 5'-triphosphate analogue, 5'-p-fluorosulfonylbenzoyladenosine (5'-FSO2BzAdo), has been studied. This interaction results in the covalent attachment of the 5'-FSO2BzAdo to the enzyme with concomitant loss of catalytic activity. Although adenine nucleotides interact with glutamine synthetase at three distinct sites--a noncovalent AMP effector site, a regulatory site of covalent adenylylation, and the catalytic ATP/ADP binding site--our studies suggest that reaction with 5'-FSO2BzAdo occurs only at the active center.

Inferred natural history of uveal melanoma.

We have observed that the fatality rate of patients with posterior uveal melanomas rapidly increased from a very low rate prior to enucleation to a maximum of 8% per year during the second year after enucleation. These data suggest to us that events related to enucleation have a deleterious effect on survival, and we have postulated that these events are either the iatrogenic dissemination of tumor cells or an adverse effect on the immune-defense system, or both. Others have proposed that the relationship between enucleation and increased mortality is only happenstance.

Statistical analysis of follow-up data concerning uveal melanomas, and the influence of enucleation.

Reappraisal of follow-up data obtained on patients whose uveal melanomas were treated by enucleation before 1955 has led to the conclusion that the operation may have had an adverse effect, accelerating dissemination and a lethal outcome, especially among patients whose tumors were large and/or contained epitheloid cells. The temporal relationship of tumor deaths to enucleation is demonstrable regardless of whether calculations represent "death density" or "hazard" functions. Use of an inferred natural history model suggests that uveal melanomas are slowly growing neoplasms.

Variability of dry mass as a fundamental biological property demonstrated for the case of Vaccinia virions.

The dry mass of individual vaccinia virions, as an example of a presumably uniform biological population, prepared in different lost at the Institute for Tropical Hygiene in Hamburg, was tested for variability by quantitative electron microscopy. A value of 5.26 X 10(-15) g for the median weight of the particle was calculated from 7,300 determinations.

Short-term changes in activity rhythms in an intertidal arthropod (Acarina: Bdella interrupta Evans).

On a marine saltmarsh, the intertidal mite, Bdella interrupta Evans, is exposed to periods of regular tidal submergence which alternate with periods of tidal emergence. The mite shows well defined day and night peaks of locomotory activity on the soil surface. During periods of tidal submergence the activity peaks showed an apparent periodicity, of around 12.

Correlation of choice reaction time performance with biorhythmic criticality and cycle phase.

The biorhythm theory correlates behavior to physical, emotional, and intellectual cycles. It states that an individual's behavior is influenced by these three cycles which begin at the moment of birth and operate thereafter simultaneously. The theory is commonly tested when the occurrence of accidents is compared to the phase of the biorhythm cycles.

Development, preparation and safety testing of a Clostridium welchii type C toxoid. II. Laboratory evaluation of potency.

The results obtained with four laboratory tests on four candidate formulations of Clostridium welchii type C vaccine for use in man have been compared with clinical responses to the same vaccines. Quantal response assays in mice appeared to reflect the ranking of the four vaccines in human subjects better than did the guinea pig tests. They also enabled the potency of the vaccine preparations to be related to an existing International Reference Preparation.

Development, preparation and safety testing of a Clostridium welchii type C toxoid. I: preliminary observations in man in Papua New Guinea.

The reactogenicity and immunogenicity of various strengths of plain and adsorbed Cl. welchii type C toxoid have been evaluated in laboratory tests and in man in Papua New Guinea. The greater antigenicity and acceptable clinical reactivity of a vaccine containing 50 total combining power units per 0.