Publications by authors named "Fortunato Cassalia"
Article Synopsis
- * The systematic literature review analyzed six relevant studies from a total of 64, examining the effectiveness of these treatments on nine patients, highlighting benefits like long-term tissue remodeling and improved skin aesthetics.
- * The findings suggest that the combination of laser therapy and fillers could enhance treatment for LS patients, indicating a need for more research to develop a solid clinical approach and improve patient quality of life.
Article Synopsis
- Deep cutaneous mycoses (DCMs) and skin fungal infections can lead to serious health issues if not properly diagnosed and treated, especially in immunocompromised individuals.
- The most common culprits are dermatophytes, which can cause skin lesions that progress to more severe conditions like ulcers and even osteomyelitis.
- Accurate diagnosis involves a combination of clinical observation, imaging, microbiological culture, and in some hard-to-diagnose cases, molecular methods; a case study illustrated the challenges in distinguishing DCMs from other conditions, highlighting the significance of awareness in at-risk populations.
Background: Atypical Spitz tumor (AST) is an intermediate category among Spitz melanocytic neoplasms. Sentinel node biopsy (SNB) has been proposed in the clinical management of AST patients, but this approach remains the subject of debate. This systematic review aims to summarize the available evidence on SNB procedures in AST patients.
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- Acral amelanotic melanomas (AAMs) are rare skin cancers found on areas like palms and soles, often misdiagnosed due to their lack of pigmentation and benign appearance, which leads to treatment delays and worse outcomes.
- A systematic review analyzed 26 cases of AAMs misdiagnosed as other conditions, revealing a balanced gender distribution, an age range of 38-91 years, and highlighting that the foot was the most common site of these lesions.
- The study emphasizes the need for more biopsy evaluations in lower extremity lesions to improve diagnosis rates, as only 7.1% of foot lesions underwent histological assessment, compared to 50% for upper extremity cases.
Psoriasis, a chronic inflammatory skin disease, goes beyond visible symptoms and affects the general well-being of patients. The aim of this study is to understand how patients with psoriasis perceive their skin characteristics and reactivity to allergens. The study population includes 11,283 participants within the European Dermato-Epidemiology Network (EDEN) Fragrance study, covering several European regions.
View Article and Find Full Text PDFPreferentially Expressed Antigen in Melanoma (PRAME), a member of the cancer/testis antigen family, is central to the field of skin cancer diagnostics and therapeutics. As a nuclear receptor and transcriptional regulator, PRAME plays a critical role in inhibiting retinoic acid signalling, which is essential for cell differentiation and proliferation. Its aberrant overexpression in various malignancies, particularly cutaneous melanoma, is associated with more aggressive tumour phenotypes, positioning PRAME as both a diagnostic and prognostic marker.
View Article and Find Full Text PDFBackground: Pancreatic cancer is notorious for its aggressive nature and low survival rate, with less than 10% of patients surviving beyond five years. Early detection is difficult, but skin metastases can be a rare but significant indicator. This systematic review focuses on the epidemiology, clinical features, and histology of skin metastases from pancreatic cancer to determine their importance in early diagnosis and overall management of the disease.
View Article and Find Full Text PDFIsolated limb perfusion (ILP) involves the local administration of high doses of anticancer drugs into a limb affected by unresectable locally advanced tumors (with special regard to in-transit melanoma metastases), minimizing systemic side effects. Tumor response to anticancer drugs may depend on the expression of apoptosis-related genes, such as SURVIVIN and MDM2. This retrospective cohort study investigated the association between tumor SURVIVIN and MDM2 expression levels and treatment response or clinical outcomes in patients undergoing ILP for in-transit melanoma metastases.
View Article and Find Full Text PDFWe present a case of sirolimus-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome in a stem cell transplant patient. Sirolimus is an immunosuppressive drug that inhibits the mammalian target of rapamycin (mTOR) pathway. A 24-year-old male with a history of acute lymphoblastic leukemia (ALL) underwent testicular extraction followed by hematopoietic stem cell transplantation (HSCT).
View Article and Find Full Text PDFBackground: Sarcoma may show similarities to malignant melanoma in terms of morphologic and immunohistochemical aspects, making it difficult to differentiate between these two neoplasms during the diagnostic process. This systematic review aims to summarize available evidence on cases of sarcoma that were initially diagnosed as melanoma.
Methods: A comprehensive search of the MEDLINE/Pubmed, EMBASE, and SCOPUS databases was conducted through March 2023.