Publications by authors named "Forti E"
Many materials have been explored for the purpose of creating structures with high radiative cooling potential, such as nanocellulose-based structures and nanoparticle-based coatings, which have been reported with environmentally friendly attributes and high solar reflectance in current literature. They each have their own advantages and disadvantages in practice. It is worth noting that nanocellulose-based structures have an absorption peak in the UV wavelengths, which results in a lower total solar reflectance and, consequently, reduce radiative cooling capabilities.
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- The text refers to a correction made to a previously published article.
- The specific article mentioned can be identified by its DOI, which is 10.1055/a-2411-1814.
- Corrections like this are common in academic publishing to address errors or inaccuracies in research.
Article Synopsis
- - The study investigated outcomes of lumen-apposing metal stents (LAMS) placement in patients with surgically altered anatomy (SAA), which is not well-documented in existing literature, involving 270 patients across 25 tertiary care centers up to November 2023.
- - Technical success of the procedures was very high at 98%, with clinical success at 97%, although there was a notable adverse event rate of 12%, with various degrees of severity recorded.
- - The results suggest that while LAMS placement in SAA is effective, due to the risk of complications, these procedures should only be performed by experienced endoscopists in specialized centers.
Background: Malignant Distal Biliary Obstruction (MBDO) is a common event occurring along the natural history of both pancreatic cancer and cholangiocarcinoma. Epidemiological and biological features make MBDO one of the key elements of the clinical management of patients suffering for of pancreatic cancer or cholangiocarcinoma. The development of dedicated biliary lumen-apposing metal stents (LAMS) is changing the clinical work up of patients with MBDO.
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- Epigenetics plays a significant role in various cancers, including diffuse large B-cell lymphoma (DLBCL), where the expression of genes BMI1, EZH2, and USP22 is being studied for their impact on prognosis.
- A multiplex digital droplet PCR (ddPCR) method was developed to measure the levels of these genes in RNA from tissue samples, showing high specificity and repeatability.
- Results indicated that elevated levels of BMI1 and USP22 correlate with worse progression-free survival (PFS) and overall survival (OS) in high-risk DLBCL patients, suggesting these genes could be potential targets for new treatments.
Background: DATATOP was a study of early Parkinson's disease (PD) conducted in the 1980 s, before mandatory folic acid fortification in the United States. Our analysis of its baseline serum samples revealed a geometric mean vitamin B12 of 369 pg/mL and homocysteine (tHcy) of 9.5μmol/l.
View Article and Find Full Text PDFPancreatic fluid collections (PFCs), including pancreatic pseudocysts (PPs) and walled-off pancreatic necrosis (WON), are common complications of pancreatitis and pancreatic surgery. Historically, the treatment of these conditions has relied on surgical and radiological approaches; however, it has later shifted toward an endoscopy-based approach. With the development of dedicated lumen-apposing metal stents (LAMS), interventional Endoscopic Ultrasound (EUS)-guided procedures have become the standard approach for PFC drainage.
View Article and Find Full Text PDFBackground And Aim: In surgically altered anatomy (SAA), endoscopic retrograde cholangiopancreatography (ERCP) can be challenging, and it remains debatable the choice of the optimal endoscopic approach within this context. We aim to show our experience and evaluate the technical and clinical success of endoscopic treatment performed in the setting of adverse events (AE) after pancreaticoduodenectomy (PD).
Methods: This study was conducted on a retrospective cohort of patients presenting biliopancreatic complications after PD from 01/01/2012 to 31/12/2022.
Pancreatic fluid collections (PFCs), including pancreatic pseudocysts (PPs) and walled-off pancreatic necrosis (WON), are common complications of pancreatitis and pancreatic surgery. Historically, the treatment of these conditions has relied on surgical and radiological approaches. The treatment of patients with PFCs has already focused toward an endoscopy-based approach, and with the development of dedicated lumen-apposing metal stents (LAMS), it has almost totally shifted towards interventional Endoscopic Ultrasound (EUS)-guided procedures.
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- Endoscopic papillectomy (EP) is considered a safe method for removing ampullary lesions, but information on handling leftover or returning adenomas is limited.
- In a study of 95 patients who underwent EP from 2011 to 2022, 28.4% showed residual adenomas, and 11.6% experienced recurrences, highlighting the need for ongoing monitoring.
- Despite complications in 25% of patients, most recurrences were successfully managed endoscopically, suggesting EP is a viable long-term treatment for these tumors.
Article Synopsis
- Endoscopic stenting, particularly using lumen-apposing metal stents (LAMS), is a key treatment for benign biliary strictures, which can recur or cause stent migration.
- A study involving 70 patients showed a 100% technical success rate and an 85.7% clinical success rate for treating these strictures with bi-flanged LAMS over six years.
- While 17.1% of patients experienced adverse events like stent migration, LAMS demonstrated effectiveness, especially in post-surgical cases, suggesting it is a safe option for managing short benign biliary strictures.
Background: Although endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) using lumen-apposing metal stents (LAMS) has become one of the treatments of choice for acute cholecystitis (AC) in fragile patients, scant data are available on real-life settings and long-term outcomes.
Methods: We performed a multicenter retrospective study including EUS-guided GBD using LAMS for AC in 19 Italian centers from June 2014 to July 2020. The primary outcomes were technical and clinical success, and the secondary outcomes were the rate of adverse events (AE) and long-term follow-up.
Objectives: Repeated endoscopic ultrasound (EUS)-guided tissue acquisition represents the standard practice for solid pancreatic lesions after previous nondiagnostic or inconclusive results. Since data are lacking, we aimed to evaluate the diagnostic performance of repeated EUS fine-needle biopsy (rEUS-FNB) in this setting. The primary outcome was diagnostic accuracy; sample adequacy, sensitivity, specificity, and safety were secondary outcomes.
View Article and Find Full Text PDFBackground: The new dedicated stents for endoscopic ultrasound (EUS)-guided transluminal drainage of peri‑pancreatic fluid collections (PFCs) demonstrated optimal efficacy and safety profiles.
Aims: This study aimed to evaluate the safety, technical and clinical success, and recurrence rate of PFCs drained with Lumen Apposing Metal Stent (LAMS) or Bi-Flanged Metal Stent (BFMS).
Methods: Data from a multicenter series of PFCs treated with LAMS or BFMS at 30 Italian centers during a 5-year period were retrieved.
Article Synopsis
- - Insulinoma is a common type of pancreatic tumor that causes symptoms due to excess insulin, and while surgery is the traditional treatment, it often leads to high rates of adverse events (AEs).
- - The study aims to compare the safety and effectiveness of endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) to surgical options, focusing on various health outcomes like AEs, quality of life, and hospital stay length.
- - An ongoing international trial named ERASIN-RCT will involve 60 patients to evaluate these treatments, hoping to determine if EUS-RFA could be a preferred first-line option for treating small insulinomas.
Background And Aims: EUS-guided gallbladder drainage (EUS-GBD) with lumen-apposing metal stents (LAMSs) has been reported as a rescue treatment with encouraging results for the relief of jaundice in patients with distal malignant biliary obstruction (DMBO) and after failure of both ERCP and EUS-guided choledochoduodenostomy.
Methods: This was a multicenter retrospective analysis of all cases of consecutive EUS-GBD with LAMSs used as a rescue treatment for patients with DMBO in 14 Italian centers from June 2015 to June 2020. Primary endpoints were technical and clinical success, whereas the secondary endpoint was the adverse event (AE) rate.
Article Synopsis
- The study evaluates the effectiveness of endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) using a new electrocautery lumen apposing metal stent (EC-LAMS) as a first-line treatment for patients with distal malignant biliary obstruction (DMBO) who may not be suitable for surgery.
- Out of 37 patients, the technical success of EC-LAMS placement was 100%, with a clinical success rate showing significant bilirubin reduction, although 10.8% experienced some adverse events, like bleeding and impaction.
- The findings suggest that EUS-GBD with EC-LAMS is a viable palliative option for managing malignant jaundice, with
Since 2014, we have been using a new endoscopic approach to improve management of biliary adverse events (BAEs) after bilio-digestive anastomosis. We provide an update about our experience at 7 years. Patients with BAEs on hepatico-jejunostomy underwent entero-enteral endoscopic by-pass (EEEB) creation between the duodenal/gastric wall and the biliary jejunal loop.
View Article and Find Full Text PDFWe analyzed the clinicopathological, cytogenetic, and molecular features of 18 primary cutaneous diffuse large B-cell lymphomas (PCDLBCLs) and 15 DLBCLs secondarily localized to the skin (SCDLBCLs), highlighting biological similarities and differences between the 2 groups. PCDLBCLs were subclassified after histopathological review as PCDLBCL-leg type (PCDLBCL-LT, 10 cases) and the PCDLBCL-not otherwise specified (PCDLBCL-NOS, 8 cases). Immunohistochemistry for Hans' algorithm markers, BCL2, and MYC was performed.
View Article and Find Full Text PDFBackground & Aims: Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) is emerging as a safe and effective treatment for pancreatic neuroendocrine tumors. We aimed to compare EUS-RFA and surgical resection for the treatment of pancreatic insulinoma (PI).
Methods: Patients with sporadic PI who underwent EUS-RFA at 23 centers or surgical resection at 8 high-volume pancreatic surgery institutions between 2014 and 2022 were retrospectively identified and outcomes compared using a propensity-matching analysis.
Background And Study Aim: Advance biliopancreatic endoscopies are nowadays performed in non-operating room anesthesia (NORA) under general anesthesia (GA). We evaluate the outcomes of non-intubated patients in prone position who received GA for endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) in a tertiary referral center for digestive endoscopy.
Patients And Methods: Anesthesiological records, anamnestic, and intraoperative data of patients who underwent advanced therapeutic biliopancreatic endoscopies at our tertiary referral center from January 2019 until January 2020 were collected in the present observational study.