Publications by authors named "Forrester N"
Background: Optimal medical therapy (OMT) for peripheral artery disease (PAD) is associated with decreased major amputation and mortality. OMT has several components, including antiplatelet and high-intensity statin therapy, blood pressure control, etc. While there are disparities in receipt of OMT among PAD patients, it is unknown if patients from disadvantaged neighborhoods, measured by the area deprivation index (ADI), are less likely to be on OMT.
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- The study assesses surgical management of pediatric lower extremity vascular injuries (PLEVI) at adult versus pediatric trauma centers.
- Between 2009 and 2022, data from 79 patients were reviewed, focusing on outcomes like amputation and fasciotomy rates.
- Results show that although injury patterns varied between centers, overall outcomes were similar, indicating that PLEVI can be effectively treated in both types of facilities.
Background: Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive disorder. This study aimed to study the genotype distribution of FCS-causing genes in the United Kingdom, genotype-phenotype correlation, and clinical differences between FCS and multifactorial chylomicronemia syndrome (MCS).
Methods: The study included 154 patients (FCS, 74; MCS, 80) from the UK FCS national registry and the UK arm of the FCS International Quality Improvement and Service Evaluation Project.
Article Synopsis
- Precision medicine relies on understanding genetic variants that cause disease and their effects, exemplified by the von Hippel-Lindau (VHL) gene involved in tumor suppression.
- VHL mutations are linked to specific types of tumors, like clear cell renal cell carcinoma, necessitating refined methods to assess their consequences.
- Researchers developed a technique to analyze nearly all single-nucleotide variants in VHL, leading to the identification of key pathogenic variants and enhancing the ability to classify these genetic changes in clinical settings.
Background: Kidney failure in young people is often unexplained and a significant proportion will have an underlying genetic diagnosis. National Health Service England pioneered a comprehensive genomic testing service for such circumstances accessible to clinicians working outside of genetics. This is the first review of patients using this novel service since October 2021, following its introduction into clinical practice.
View Article and Find Full Text PDFBackground: Studies suggest that ambulation after major lower extremity amputation (LEA) is low and mortality after LEA is high. Successful prosthetic fitting after LEA has a significant quality of life benefit; however, it is unclear if there are benefits in post-LEA mortality. Our objective was to examine a contemporary cohort of patients who underwent LEA and determine if there is an association between fitting for a prosthetic and mortality.
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- Around 158,500 people in the U.S. have undiagnosed HIV, which complicates treatment and health outcomes, especially for those on immunosuppressive therapy.
- Patients taking these therapies are at heightened risk for infections, yet routine HIV testing before treatment isn't standard practice.
- A case study of three patients shows that undiagnosed HIV led to severe complications during their course of immunosuppressive treatment, highlighting the need for pre-treatment HIV screening.