Publications by authors named "Forrest W Williard"
Article Synopsis
- The study compared peritoneal metastases from appendiceal cancers (pAC) and colorectal cancers (pCRC) using comprehensive tumor profiling techniques to understand their genetic differences.
- In the analysis of 136 pAC and 348 pCRC samples, pCRC showed a significantly higher frequency of pathogenic variants in several key genes, such as APC and TP53, while pAC had unique mutations.
- Although pCRC had a higher median tumor mutational burden (TMB), both types had similar rates of TMB-high tumors, indicating that pAC mutations may represent potential biomarkers for further research.
Background And Objectives: Peritoneal metastases (PM) from primary colorectal cancer (pCRC) are associated with poor outcomes; however, molecular differences are not well defined.
Methods: We compared unpaired tumor profiles of patients with pCRC and PM from Caris Life Sciences. Testing included next-generation sequencing of 592 genes, microsatellite instability (MSI) and tumor mutational burden (TMB).