Thyroid hormones mediate the impact of early-life stress on ventral tegmental area gene expression and behavior.

Proper thyroid function is essential to the developing brain, including dopamine neuron differentiation, growth, and maintenance. Stress across the lifespan impacts thyroid hormone signaling and anxiety disorders and depression have been associated with thyroid dysfunction (both hypo- and hyper-active). However, less is known about how stress during postnatal development impacts thyroid function and related brain development.

Thyroid hormones mediate the impact of early-life stress on ventral tegmental area gene expression and behavior.

Proper thyroid function is essential to the developing brain, including dopamine neuron differentiation, growth, and maintenance. Stress across the lifespan impacts thyroid hormone signaling and anxiety disorders and depression have been associated with thyroid dysfunction (both hypo- and hyper-active). However, less is known about how stress during postnatal development impacts thyroid function and related brain development.

African striped mice (Rhabdomys pumilio) as a neurobehavioral model for male parental care.

Parental care is diversely demonstrated across the animal kingdom, such that active practitioners and repertoires of parental behavior vary dramatically between and within taxa. For mammals, maternal care is ubiquitous while paternal and alloparental care are rare. The African striped mouse, a rodent species in the family Muridae, demonstrates maternal, paternal, and alloparental care.

Oxytocin receptor is not required for social attachment in prairie voles.

Prairie voles are among a small group of mammals that display long-term social attachment between mating partners. Many pharmacological studies show that signaling via the oxytocin receptor (Oxtr) is critical for the display of social monogamy in these animals. We used CRISPR mutagenesis to generate three different Oxtr-null mutant prairie vole lines.

Introduction to Special Issue on Affective Science in Animals: Toward a Greater Understanding of Affective Processes in Non-Human Animals.

How should we characterize the affective lives of non-human animals? There is a large body of work studying affective processes in non-human animals, yet this work is frequently overlooked. Ideas about the affective lives of animals have varied across culture and time and are reflected in literature, theology, and philosophy. Our contemporary ideas about animal affect are philosophically important within the discipline of , and these ideas have consequences in several domains, including animal husbandry, conservation, and human and veterinary medicine.

Neuroimaging of human and non-human animal emotion and affect in the context of social relationships.

Long-term relationships are essential for the psychological wellbeing of humans and many animals. Positive emotions and affective experiences (e.g.

Interactions between the opioid system, corticotropin-releasing hormone and oxytocin in partner loss.

Selective adult social attachments, or 'pair bonds', represent central relationships for individuals in a number of social species, including humans. Loss of a pair mate has emotional consequences that may or may not diminish over time, and that often translate into impaired psychological and physical health. In this paper, we review the literature on the neuroendocrine mechanisms for the emotional consequences of partner loss, with a special focus on hypothesized interactions between oxytocin, corticotropin-releasing hormone and the opioid system.

Compositional variation in early-life parenting structures alters oxytocin and vasopressin 1a receptor development in prairie voles (Microtus ochrogaster).

Paternal absence can significantly alter bio-behavioural development in many biparental species. This effect has generally been demonstrated by comparing the development of offspring reared under biparental care with those reared by a single mother. However, studies employing this design conflate two significant modifications to early-life experience: removal of father-specific qualities and the general reduction of offspring-directed care.

Revisiting paternal absence: Female alloparental replacement of fathers recovers partner preference formation in female, but not male prairie voles (Microtus ochrogaster).

In prairie voles (Microtus ochrogaster), biparental care of offspring is typical, and paternal absence in the pre-weaning development of offspring alters biobehavioral development. We sought to determine whether this altered development is due to the absence of specific paternal qualities or a general reduction in pup-directed care. We compared the biobehavioral development of pups reared under conditions of biparental (BPC), maternal-plus-alloparental (MPA; i.

Mothers, Fathers, and Others: Neural Substrates of Parental Care.

Parental care is essential for the survival of offspring in altricial mammalian species. However, in most mammals, virgin females tend to avoid or attack infants. Moreover, most males demonstrate avoidance and aggression toward infants, and have little to no involvement in parental care.

Longitudinal Trajectories and Inter-parental Dynamics of Prairie Vole Biparental Care.

For altricial mammalian species, early life social bonds are constructed principally between offspring and their mothers, and the mother-offspring relationship sets the trajectory for offspring bio-behavioral development. In the rare subset of monogamous and biparental species, offspring experience an expanded social network which includes a father. Accordingly, in biparental species fathers also have the potential to influence trajectories of offspring development.

Titi Monkeys as a Novel Non-Human Primate Model for the Neurobiology of Pair Bonding .

It is now widely recognized that social bonds are critical to human health and well-being. One of the most important social bonds is the attachment relationship between two adults, known as the . The pair bond involves many characteristics that are inextricably linked to quality of health, including providing a secure psychological base and acting as a social buffer against stress.