Publications by authors named "Forogh Soltaninejad"
Article Synopsis
- - The study examined the sleep patterns of patients with obesity hypoventilation syndrome (OHS) who are opium addicts, on methadone maintenance treatment (MMT), or non-addicts, using polysomnographic (PSG) data.
- - A total of 75 patients were categorized into three groups, and results indicated that while the overall apnea hypopnea index was similar across groups, the opium addicts had significantly longer apnea durations, while those on MMT showed worse hypopnea and oxygen saturation measures.
- - The findings highlighted that sleep disturbances were more pronounced in the MMT group compared to opium addicts, suggesting a need for more research on how both substances affect sleep in OHS patients.
Article Synopsis
- - The prevalence of obstructive sleep apnea (OSA) increases in pregnant women, negatively impacting both maternal and fetal health.
- - A systematic review tested the effectiveness of three questionnaires (Berlin, STOP-Bang, and Epworth Sleepiness Scale) for detecting OSA in pregnant women, finding moderate accuracy overall.
- - The Berlin and STOP-Bang questionnaires performed better than the Epworth Sleepiness Scale, but all showed limited sensitivity and specificity, indicating a need for further research on alternative screening methods.
Article Synopsis
- The study aimed to explore how gas exchange and daytime sleepiness improve in patients with obesity hypoventilation syndrome (OHS) using daytime and night-time sleep studies.
- A total of 101 patients were analyzed, with no significant differences in demographics or initial health markers between the two study groups, but both showed significant improvements after 12 weeks of treatment.
- The results suggested that daytime sleep studies (DSPSG) are a valid alternative for diagnosing OHS and titration, as there were no significant differences in effectiveness compared to night-time studies (NSPSG).
Article Synopsis
- Early treatment of COVID-19 with corticosteroids was studied to see if it could prevent hospitalization in nonsevere cases.
- In a randomized trial with 75 patients, those who received prednisolone showed a slightly higher hospitalization rate (10.8%) compared to the placebo group (7.9%), but the difference was not statistically significant.
- Based on the findings, the study concluded that corticosteroids should not be used for outpatient treatment of nonsevere COVID-19 as they did not demonstrate a beneficial effect.
Introduction: Coronary artery disease (CAD) is considered an independent risk factor for COVID-19. However, no study has specifically examined the clinical manifestations and outcomes of COVID-19 in patients with ischemic heart disease (IHD).
Methods: In a retrospective case-control study between 20 March 2020 to 20 May 2020, the medical record of 1611 patients with laboratory-confirmed SARS-CoV-2 infection was reviewed.
Article Synopsis
- The study explores the effectiveness of nighttime noninvasive ventilation (NIV) for patients with interstitial lung disease (ILD) who have hypercapnic respiratory failure.
- In a trial with 20 participants, those using NIV showed notable improvements in physical and social functioning over 30 days compared to the control group, despite no significant difference in dyspnea between the two groups.
- The findings suggest that NIV can enhance quality of life related to physical health in ILD patients, indicating potential benefits for this treatment approach.
Article Synopsis
- The study assessed the effectiveness of thalidomide on patients with moderate COVID-19 pneumonia compared to standard treatment alone in a randomized controlled trial.
- A total of 46 patients participated, with thalidomide showing no significant difference in time to clinical recovery or ICU admissions compared to the control group.
- The findings concluded that thalidomide did not provide additional benefits over usual treatment for improving clinical outcomes in moderate COVID-19 cases.
Article Synopsis
- This study aimed to assess whether Favipiravir could prevent hospitalization in symptomatic COVID-19 patients who were not hospitalized.
- Conducted as a triple-blind randomized controlled trial in Isfahan, Iran, 77 patients received either Favipiravir or a placebo over five days, with hospitalization rates monitored up to 28 days.
- The results indicated no significant reduction in hospitalization rates between the Favipiravir group (10.5%) and the placebo group (5.1%), leading to the conclusion that Favipiravir is not effective in reducing hospitalizations for mild to moderate COVID-19 cases in outpatient settings.
Background: Acute kidney injury (AKI) has the most prevalent complications in COVID-19 patients. A variety of factors is involved in the disease progression and its associated outcomes. The present study aimed at both examining the correlated clinical features of COVID-19 disease and AKI and evaluating its clinical outcomes.
View Article and Find Full Text PDFBackground: COVID-19, with its high transmission and mortality rates and unknown outcomes, has become a major concern in the world. Among people with COVID-19, severe cases can quickly progress to serious complications, and even death. So, the present study aimed to examine the relationship between the severity of the disease and the outcome in patients afflicted by COVID-19 during hospitalization.
View Article and Find Full Text PDFArticle Synopsis
- The study examined the link between metabolic syndrome (MS) and obstructive sleep apnea (OSA) by comparing first-degree relatives (FDRs) of OSA patients to healthy controls.
- It involved 39 FDRs and matched controls, assessing factors like blood pressure, weight, and biochemical indices to evaluate the prevalence of MS.
- Results showed no significant difference in MS frequency between the two groups, but higher hypertension rates were noted in the FDR group, indicating the need for further research on hereditary factors in OSA.
Article Synopsis
- COVID-19 has been linked to high rates of heart issues, particularly myocardial injury, but there's limited research on how it affects heart function using echocardiography.
- A study of 64 severely ill COVID-19 patients revealed that about 32% had reduced left ventricular function, though only a small number had significant dysfunction (LVEF under 40%).
- Elevated cardiac troponin I levels were found in 60.9% of patients and were associated with higher mortality risk, alongside other ECG changes indicating poor outcomes.
Background: In this study, we summarized the data on gastrointestinal (GI) involvement and the potential association with clinical outcomes among the patients admitted to Khorshid Hospital.
Materials And Methods: We investigated 1113 inpatients (≥18 years old) diagnosed with coronavirus disease-2019 (COVID-19) from March to June 2020 in Khorshid Hospital. We collected demographic details, clinical information, vital signs, laboratory data, treatment type, and clinical outcomes from patients' medical records.
Background: Since the beginning of the coronavirus disease of 2019 (COVID-19) pandemic, concerns raised by the growing number of deaths worldwide. Acute respiratory distress syndrome (ARDS) and extrapulmonary complications can correlate with prognosis in COVID-19 patients. This study evaluated the association of systemic complications with mortality in severely affected COVID-19 patients.
View Article and Find Full Text PDFArticle Synopsis
- * Among 553 patients, those with secondary infections were predominantly older men, and they were almost universally prescribed empirical antibiotics (usually meropenem and levofloxacin) before receiving positive culture results.
- * The findings highlighted a concerning level of drug resistance, especially to carbapenem antibiotics, and revealed an alarmingly high mortality rate (83%) among patients with secondary infections compared to the overall COVID-19 patient mortality rate of 38.1%.
Article Synopsis
- * Key findings indicated that longer hospital stays, pre-existing chronic conditions, high pulse rates, and abnormal laboratory results significantly increased mortality risks.
- * Specific lab indicators, like high neutrophil/lymphocyte ratios and elevated creatinine and potassium levels, were identified as strong independent predictors of in-hospital death from COVID-19.
Article Synopsis
- Clinicians need simple tools to identify hospitalized COVID-19 patients at high mortality risk to enhance resource management and patient care in hospitals.* -
- A study on 630 COVID-19 patients used competing risk methods to develop a death risk chart based on easily measurable factors like age and oxygen saturation, achieving high accuracy in distinguishing between discharged and deceased patients.* -
- The resulting personalized mortality risk calculator provides valuable guidance for physicians in making critical treatment decisions for COVID-19 patients.*
Article Synopsis
- * An interventional clinical trial was conducted, measuring HRV before and after patients received three months of BiPAP treatment, showcasing significant relationships between hypoventilation and HRV.
- * The study concludes that improved respiration from BiPAP may enhance the functioning of the autonomic nervous and cardiovascular systems, suggesting HRV metrics as useful for monitoring cardiovascular risks associated with OHS.
Article Synopsis
- The study investigated sleep and mood disturbances in healthcare workers (HCWs), examining their relationship with COVID-like symptoms among those with and without a positive Coronavirus test.
- Conducted via an anonymous survey during the pandemic, data were collected from 372 adult HCWs, evaluating factors such as anxiety, depression, and insomnia.
- Results showed that HCWs with a positive COVID-19 test experienced significantly more mood and sleep disturbances, and significant associations were found between these disturbances and COVID-like symptoms, particularly in those without a confirmed infection.
Article Synopsis
- * The primary issues for hospital admission included fever, dry cough, and fatigue, with significant comorbidities found among patients being hypertension, diabetes, and ischemic heart disease.
- * Key risk factors identified for severe outcomes (like death or need for intensive care) were low oxygen saturation and specific blood count issues, highlighting the importance of monitoring these factors for better patient management.
Background: Obstructive sleep apnea (OSA) is a common health issue with serious complications. Regarding the high cost of the polysomnography (PSG), sensitive and inexpensive screening tools are necessary. The objective of this study was to evaluate the predictive value of anthropometric and Mallampati indices for OSA severity in both genders.
View Article and Find Full Text PDFBackground: This study aimed to assess the outcomes of bi-level positive airway pressure (BIPAP) therapy among patients with obesity hypoventilation syndrome (OHS).
Materials And Methods: In this prospective observational study, a total of 30 patients with OHS, who were subjected to BIPAP therapy, were included. The peripheral capillary oxygen saturation (SPO), partial pressure of carbon dioxide (PCO), body mass index (BMI), and body composition indices, including total body fat (TBF), total body protein (TBP), total body mineral (TBM), and total body water (TBW), were measured using standard procedures at baseline and one week, one month, and six months after the onset of treatment.
Background: Nowadays, the most practical approaches used to treat sleep apnea, are Continuous Positive Airway Pressure (CPAP), Bi-level Positive Airway Pressure therapy (BPAP), supplemental O, servoventilation and/or a combination of these approaches simultaneously. However, each leads to different consequences in opioid related Central Sleep Apnea (CSA) patients. Given the high prevalence of CSA and frequently use of opioids worldwide, it seems that evaluation of the condition in these patients is required to determine their responsiveness to the above mentioned treatments and to choose the most appropriate therapy.
View Article and Find Full Text PDFBackground: Most of patients with Obstructive Sleep Apnea (OSA) are at risk of metabolic syndrome. The treatment of choice for OSA patients is the Continuous Positive Airway Pressure (CPAP). Reports about the effect of CPAP on metabolic parameters are controversial.
View Article and Find Full Text PDFObstructive sleep apnea (OSA) is the most common sleep-related breathing disorder and is associated with significant morbidity. We sought to present an updated systematic review of the literature on the accuracy of screening questionnaires for OSA against polysomnography (PSG) as the reference test. Using the main databases (including Medline, Cochrane Database of Systematic Reviews and Scopus) we used a combination of relevant keywords to filter studies published between January 2010 and April 2017.
View Article and Find Full Text PDF