Coronary Artery Calcification and Risk of Cardiovascular Disease and Death Among Patients With Chronic Kidney Disease.

Importance: Coronary artery calcification (CAC) is highly prevalent in dialysis-naive patients with chronic kidney disease (CKD). However, there are sparse data on the association of CAC with subsequent risk of cardiovascular disease and all-cause mortality in this population.

Objective: To study the prospective association of CAC with risk of cardiovascular disease and all-cause mortality among dialysis-naive patients with CKD.

Edge control in a computer controlled optical surfacing process using a heterocercal tool influence function.

Edge effect is regarded as one of the most difficult technical issues in a computer controlled optical surfacing (CCOS) process. Traditional opticians have to even up the consequences of the two following cases. Operating CCOS in a large overhang condition affects the accuracy of material removal, while in a small overhang condition, it achieves a more accurate performance, but leaves a narrow rolled-up edge, which takes time and effort to remove.

Arterial stiffness, central pressures, and incident hospitalized heart failure in the chronic renal insufficiency cohort study.

Background: Chronic kidney disease is associated with an increased risk of heart failure (HF). We aimed to evaluate the role of large artery stiffness, brachial, and central blood pressure as predictors of incident hospitalized HF in the Chronic Renal Insufficiency Cohort (CRIC), a multiethnic, multicenter prospective observational study of patients with chronic kidney disease.

Methods And Results: We studied 2602 participants who were free of HF at baseline.

Limited health literacy is associated with low glomerular filtration in the Chronic Renal Insufficiency Cohort (CRIC) study.

Background: Low health literacy in the general population is associated with increased risk of death and hospitalization. The evaluation of health literacy in individuals with predialysis chronic kidney disease (CKD) is limited.

Methods: We conducted a cross-sectional study to evaluate the associations of limited health literacy with kidney function and cardiovascular disease (CVD) risk factors in 2,340 non-Hispanic (NH) Whites and Blacks aged 21 - 74 years with mild-to-moderate CKD.

Approximation of normalized point source sensitivity using power spectral density and slopes of wavefront aberration.

We have investigated two approximation methods for estimating the normalized point source sensitivity (PSSN), which is a recently developed optical performance metric for telescopes. One is an approximation based on the power spectral density (PSD) of the wavefront error. The other is the root-square-sum of the wavefront slope.

Factors associated with depressive symptoms and use of antidepressant medications among participants in the Chronic Renal Insufficiency Cohort (CRIC) and Hispanic-CRIC Studies.

Background: Depressive symptoms are correlated with poor health outcomes in adults with chronic kidney disease (CKD). The prevalence, severity, and treatment of depressive symptoms and potential risk factors, including level of kidney function, in diverse populations with CKD have not been well studied.

Study Design: Cross-sectional analysis.

Symptomatic hyponatremia during glomerular filtration rate testing.

Hyponatremia affects nearly one in five of all hospitalized patients. Severe hyponatremia is associated with significant morbidity and mortality, and is therefore important to recognize. Prior reports have linked duloxetine with hyponatremia, but it is uncommon.

A psychophysiologic reaction to application of ambulatory blood pressure monitor: fact or artifact?

Background: The study investigated the clinical significance of relatively high blood pressure (BP) elevations during the calibration of the ambulatory blood pressure monitor (ABPM).

Methods: Inferences were drawn from the analysis of differences between 'M', the average of five manually triggered responses, and 'W', the average daytime BP. M-W differences were calculated from ABPM recordings of consecutive patients (N=276), grouped diagnostically, on the basis of ABPM results, into normotensive (71), untreated hypertensive (77), and treated hypertensive (128).

Hypertension awareness, treatment, and control in adults with CKD: results from the Chronic Renal Insufficiency Cohort (CRIC) Study.

Background: A low rate of blood pressure control has been reported in patients with chronic kidney disease (CKD). These data were derived from population-based samples with a low rate of CKD awareness.

Study Design: Cross-sectional.

A randomized, double-blind, placebo-controlled trial of casein protein hydrolysate (C12 peptide) in human essential hypertension.

Background: Many patients seek complementary medicine treatments like neutraceuticals for common conditions such as hypertension.

Methods: We conducted a placebo-controlled prospective randomized crossover study in 10 hypertensive subjects to determine whether a single dose of a hydrolysate of bovine milk protein (designated C12 peptide; low and high dose), either alone or combined with alginic acid (low and high dose), reduced daytime blood pressure (BP), as determined by ambulatory BP monitoring.

Results: Within the five treatment regimens a significant reduction of 9.

Thrombomodulin distribution during murine development.

Thrombomodulin is a transmembrane glycoprotein involved in the regulation of clot formation. Previous work has shown that in the adult mouse, thrombomodulin expression is primarily located on the luminal surface of endothelial cells; whereas during development, thrombomodulin has been localized to the placental parietal endoderm, the neuroepithelium, head mesenchyme, lung bud, and atrium of Day 10.5 post coitum embryos.