Is the clinical course of HIV-1 changing? Cohort study.

Objective: To assess whether the clinical course of HIV infection has changed from 1985 to 1995.

Design: Cohort Study.

Setting: Infectious disease clinic.

Seroconversion to HBV associated with seroconversion to HIV in a cohort of intravenous drug misusers in Turin, Italy.

Between March 1986 and March 1994, the seroconversion to HBV associated to the seroconversion to HIV was investigated in 120 HIV seroconverters drawn from 2368 i.v. drug misusers screened for HIV, HBV and STDs.

Seroprevalence, risk factors and attitude to HIV-1 in a representative sample of lesbians in Turin.

Objective: To estimate the HIV-1 seroprevalence, behavioural risks and attitude to HIV-1 infection among lesbians.

Setting: Institute of Infectious Diseases, University of Turin, Italy.

Subjects: From March 1992 to May 1993, 181 lesbians were tested for HIV-1 and included in the study.

[Early diagnosis of HCMV infections in patients undergoing transplantation of the kidney].

HCMV infection is a major cause of morbidity and mortality following kidney transplantation. Clinical diagnosis is difficult, and rapid and sensitive diagnostic methods are needed since antiviral therapy is available. One hundred-forty-five consecutive kidney-transplanted patients were studied during a period of three months after transplantation.

Unusual eruption of cutaneous metastases from occult gastric carcinoma shortly after HIV-1 infection.

We report a case of eruptive metastases to the skin of the face and neck from a hitherto unknown gastric carcinoma, occurring in a fifty-two-year-old man (a regular blood donor), about six months after he contracted human immunodeficiency virus-1 infection. The eruption, consisting of more than thirty pea-sized cutaneous nodules appeared within about twenty days. The patient complained of epigastric pain and weight loss.

Risk of developing AIDS after primary acute HIV-1 infection.

We enrolled 134 newly human immunodeficiency virus type 1 (HIV-1)-infected subjects in a prospective study to determine the natural history of the infection and evaluate the risk of developing AIDS after acute primary HIV-1 infection (API). Twenty-three patients were observed during an acute primary HIV-1 infection, and 111 were asymptomatic seroconverters. Acute primary HIV-1 infection was more frequently observed in subjects who had acquired the infection through sexual transmission.