Publications by authors named "Fonseca S"

Objective: To assess whether individual diagnosis of low urinary iodine concentration (UIC) in pregnant women is associated with adverse maternal and neonatal outcomes.

Methods: Studies that compared pregnant women with UIC <150 μg/L and those with UIC 150-249 μg/L were systematically reviewed. MEDLINE, EMBASE, LILACS, and CENTRAL were our source databases.

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  • Runners who don't allow enough recovery time after training may be at a higher risk for injuries due to fatigue and altered movement patterns.
  • A study looked at how different running intensities affect lower-limb joint movements and coordination during a single-leg squat in 30 healthy runners.
  • Immediate and longer-term changes showed that coordination patterns became less adaptive (more regular) after moderate and high-intensity runs, but traditional kinematic analysis did not effectively capture these changes.
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Objective: To compare the effect of different preemptive and preventive analgesia strategies involving oral coadministration of ibuprofen-arginine (770 mg)-Ib-Ar and dexamethasone (8 mg)-DX, and their respective placebos (P-Ib-Ar and P-DX), four evaluation groups on inflammatory and laboratory parameters, impact on quality of life, pain catastrophizing perception and sleep quality related after lower third molar surgery.

Study Design: A randomized split-mouth, triple-blind, controlled clinical trial was conducted with 48 volunteers. They were allocated depending on the use of Ib-Ar or DX, 1 hour before surgery or immediately postoperatively, discriminating the groups: G1 (Ib-Ar + DX), G2 (Ib-Ar + P-DX), G3 (P-Ib-Ar + DX), and G4 (P-Ib-Ar + P-DX).

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The anatomical connection between latissimus dorsi (LD), thoracolumbar fascia, and contralateral gluteus maximus (GM) enables myofascial force transmission (MFT) between the shoulder, trunk, and hip. This study investigates whether regular sports practice, specifically running, influences this MFT pathway. Given the potential changes in tissue stiffness from sports practice and the importance of this property for MFT, we hypothesize that runners may exhibit greater MFT between the LD and GM, resulting in altered passive properties of the lumbar and hip regions during LD contraction.

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Immunological memory, a fundamental immune system mechanism, is instrumental in long-term protection. Successful vaccines can elicit and sustain immunological memory against pathogens for the long term. Memory B cells (MBC) are key players in secondary responses due to their longevity and rapid differentiation into high-affinity antibody-secreting cells upon second antigen exposure.

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  • This study examines how hip and foot biomechanical factors affect foot pronation while walking.
  • It identified four profiles of biomechanical factors that correspond to greater or lower levels of foot pronation, involving measurements like foot-ankle alignment and hip stiffness.
  • The findings suggest that certain combinations of these factors can help predict foot pronation, which may assist in assessing individuals with varying levels of pronation.
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In British Columbia, Canada, unidentified skeletal human remains are often recovered by law enforcement or civilians and there is a question if they are modern and of medicolegal significance, or historical or archaeological. We used relatively fast and inexpensive carbon and nitrogen stable isotope analysis of human bone collagen from a selection of these remains (n = 48) combined with a logistic regression model to classify remains as modern, historical, or archaeological. We then confirmed our temporal classification through directly radiocarbon dating each individual and found that we could predict the temporal group with 93% accuracy.

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This study investigated the kinematic (KmS) and kinetic (KnS) strategies integrating the trunk and lower limbs to achieve maximal kicking performance. Although strategies consisting of individual joint movements or moments are known, strategies combining joint movements or moments of the trunk and lower limbs have been less studied. Fifty adult amateur soccer players were assessed.

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  • Aging can lead to sarcopenic obesity, a condition where individuals are obese while also experiencing muscle loss and decreased strength due to sarcopenia.
  • The study evaluated 156 older women to analyze the effects of obesity, sarcopenia, and sarcopenic obesity on body composition, functional performance, and muscle strength; results showed that 32.7% had obesity, 15.4% had sarcopenia, and 25% were classified as having sarcopenic obesity.
  • Findings revealed that women with sarcopenic obesity had worse physical performance and lower muscle-specific strength compared to those without, highlighting the need to consider muscle strength in diagnosing and addressing sarcopenic obesity in
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  • Smoking is a leading cause of preventable death globally, with nicotine affecting brain activity related to addiction and heart function, potentially leading to heart rhythm issues.
  • A study was conducted on Wistar rats to examine EEG and ECG patterns during nicotine exposure, withdrawal, and relapse, focusing on the impact on brainwaves and heart conduction.
  • Findings reveal that high-frequency brainwaves relate to nicotine dependence, while withdrawal emphasizes slower brain oscillations tied to cravings; nicotine can cause heart abnormalities that slightly improve with withdrawal but worsen during relapse.
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The photophysics and nonlinear optical responses of a novel nitrothiazol-methoxyphenol molecule were investigated using density functional theory (DFT) and time-dependent density functional theory (TD-DFT) methods with the polarizable continuum model to take the solvent effect into account. Special attention is paid to the description of the lowest absorption band, characterized as a strong π → π* state in the visible region of the spectrum. The TD-DFT emission spectrum analysis reveals a significant Stokes shift of more than 120 nm for the π → π* state in gas phase condition.

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  • Abscisic acid (ABA) is crucial for plant development and helps plants respond to environmental stress by regulating key signaling pathways.
  • The ubiquitin-proteasome system, specifically CULLIN4-RING (CRL4) E3 ubiquitin ligases, negatively regulates ABA receptor PYL8 through a complex known as CDD, leading to PYL8 degradation.
  • ABA enhances the stability of PYL8 by disrupting CRL4-CDDD complexes and altering their interaction with the COP9 signalosome, demonstrating how plants use hormones to protect their receptors from degradation.
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Purpose: This study aimed to identify predictive factors for the improvement of best-corrected visual acuity (BCVA) and reduction of central macular thickness (CMT) after treatment of macular edema (ME) due to branch retinal vein occlusion (BRVO) in a real-world setting.

Methods: This retrospective study included patients with ME secondary to BRVO who were treated with intravitreal injection of bevacizumab as the first-line therapy and were followed up for 12 months. Demographic and clinical data, in addition to baseline spectral domain optical coherence tomography (SD-OCT) features, were considered as possible biomarkers of final BCVA and CMT.

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Background And Aim: Cirrhosis is characterized by structural and functional alterations of the liver. Melatonin (MLT) has antioxidant properties. Physical exercise (EX) can reverse muscle loss in cirrhotic patients.

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The 4th Forensic DNA Symposium in Africa underscored the critical role of regional collaboration in advancing forensic sciences, with a particular focus on forensic DNA examinations, databases, and humanitarian initiatives. The symposium aimed to assess the current forensic DNA capabilities across African countries and develop strategies to expand and better utilize DNA platforms. Key findings from the symposium highlight the necessity for enhanced cooperation among African nations to build robust forensic DNA databases and improve data-sharing mechanisms.

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Objective: The objective of this study was to conduct an integrative review, addressing the key findings, biological functions, and clinical significance of these biomolecules in solid tumors.

Methods: This document analyzes the main data on the involvement of snoRNAs in solid tumors. For this, Pubmed and Science direct were used, with keywords.

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  • Perivascular epithelioid cell tumor (PEComa) is generally a benign tumor, but this report details two cases of advanced malignant PEComa in women aged 74 and 50, leading to complex surgical management.* -
  • The first patient presented with a large, painful abdominal mass and difficult pathological diagnosis, while the second patient showed typical immunohistochemical patterns and received targeted therapy, resulting in no recurrence after 8 months.* -
  • The study highlights the variability in clinical features of metastatic PEComa and the challenges in diagnosis, noting that there are currently no definitive diagnostic markers for these tumors.*
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An increasing number of consumers demand healthier, more convenient, and sustainable food products, including rice, a staple worldwide. Food manufacturers have responded to this trend by considering food's intrinsic and extrinsic aspects. This study evaluated the importance of variety, processing, and claims on willingness to try ready-to-eat rice (RTE-rice).

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  • Cannabis is the most widely used illegal drug globally, and as legal access increases, methods to analyze its active compounds in biological samples—like oral fluid—are evolving.
  • A new extraction method was developed to efficiently isolate cannabinoids (like THC and CBD) from 0.2 mL of oral fluid using a combination of methanol and acetonitrile, followed by liquid chromatography and mass spectrometry for analysis.
  • The method yielded reliable results with low detection limits and showed no interference, making it rapid, precise, and suitable for routine testing of cannabis metabolites.
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  • * The results showed no significant differences in the number of normal and developing follicles between the PAM treatments and control after both time periods, indicating that PAM did not harm reproductive health.
  • * However, after 90 days, only the 5% PAM treatment affected the ovarian stromal cell density, suggesting minor impacts at this concentration, but overall, the study concluded that PAM supplementation was safe for animal consumption.
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 To compare the spatial-temporal parameters and walking kinematics of toddlers wearing biomimetic shoes, regular shoes (daily use owned shoes), and barefoot.  Spatial-temporal parameters (speed, step length, and stride width), the mean vertical displacement of the center of mass (COM), knee flexion peak, and maximal foot height were analyzed.  Children were not different in biomimetic shoes and barefoot conditions on speed, step length, and COM vertical displacement.

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Background: Strengthening the hip and trunk muscles may decrease foot pronation in upright standing due to expected increases in hip passive torque and lower-limb external rotation. However, considering the increased pronation caused by a more varus foot-ankle alignment, subjects with more varus may experience smaller or no postural changes after strengthening.

Objective: To investigate the effects of hip and trunk muscle strengthening on lower-limb posture during upright standing and hip passive torque of women with more and less varus alignment.

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This study aimed to identify the clinical and biomechanical factors of subjects with excessive foot pronation who are not responsive (i.e., "non-responders") to medially wedged insoles to increase knee adduction external moment.

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Cervical Cancer (CC) is one of the most prevalent neoplasms among women, considered the leading cause of gynecological death worldwide, and the fourth most common type of cancer. Regional metastasis is closely related to the low effectiveness of treatment, and validating biomarkers can optimize accuracy in diagnosis and prognosis. Among the potential biomarkers associated with disease metastasis are circular RNAs (circRNAs), whose altered expression has been linked to CC progression.

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