[Innovations in forensic medicine: accuracy, evidence and effectiveness of expertises in emergencies in case of mass fatality].

The article presents the main innovative methods used in forensic expert practice at the current stage, reveals the principle and algorithms of the developed software complex for registration and identification of the deceased. The proposed program automatically generates four documents, which reduces the time required for forensic expertise in the conditions of mass admission of deceased. The article's authors substantiate prospects of further application of computer technologies in forensic practice to improve organizational and methodological activities in emergencies with a large number of deceased.

Development of a digital platform for nursing monitoring of patients with chronic kidney failure.

Purpose: This study aims to develop and propose the key criteria and elements necessary to be included in digital platforms for achieving high-quality monitoring of patients with chronic kidney failure.

Methods: The research was conducted from 2021 to 2023 in Moscow, Russia. A total of 75 patients comprised the experimental group (digital monitoring), while an equal number constituted the control group (standard nursing care).

[Assessment of systemic inflammation activity, myocardial structure and functional features, their relationship in patients with multiple myeloma, receiving bortezomib therapy].

Aim: To study the dynamics of calculated indices [neutrophil-lymphocyte ratio (NLR); systemic inflammation index (SIV)] and biomarkers of systemic inflammation [interleukin-1β (IL-1β); high-sensitivity C-reactive protein (hsCRP)], parameters of the structure-and-function state of the myocardium and intracardiac hemodynamics, and their relationship in patients newly diagnosed with multiple myeloma (MM) at the onset of the disease and after 6 courses of chemotherapy (CT) containing the proteasome inhibitor bortezomib.

Material And Methods: This prospective study included 30 patients aged 63.8±10.

Differential induction of C6 glioma apoptosis and autophagy by 3β-hydroxysteroid-indolamine conjugates.

In a previous work, we reported the synthesis of four novel indole steroids and their effect on rat C6 glioma proliferation in vitro. The steroid derived from dehydroepiandrosterone and tryptamine (IS-1) was the most active (52 % inhibition at 10 µM), followed by one of the epimers derived from pregnenolone and tryptamine (IS-3, 36 % inhibition at 10 µM). By contrast, the steroid derived from estrone and tryptamine (IS-2) showed negligible activity at 10 µM.

Russian nurses' readiness for transcultural care of palliative patients.

Palliative care involves an approach aimed at improving the quality of life of patients and their families, who are forced to cope with the problems associated with life-threatening diseases. This definition includes a growing group of patients around the world. It requires an extension of the definition of patients in need of palliative care in countries such as Russia and a significant improvement in the work of nursing personnel with these patients.

Technogenic Fiber Wastes for Optimizing Concrete.

A promising method of obtaining mineral fiber fillers for dry building mixtures is the processing of waste that comes from the production of technogenic fibrous materials (TFM). The novelty of the work lies in the fact that, for the first time, basalt production wastes were studied not only as reinforcing components, but also as binder ones involved in concrete structure formation. The purpose of the article is to study the physical and mechanical properties of waste technogenic fibrous materials as additives for optimizing the composition of raw concrete mixes.

Chronic, acute and protocol-dependent effects of exercise on psycho-physiological health during long-term isolation and confinement.

Exercise could prevent physical and psychological deteriorations, especially during pandemic times of lock-down scenarios and social isolation. But to meet both, the common exercise protocols require optimization based on holistic investigations and with respect to underlying processes. This study aimed to explore individual chronic and acute effects of continuous and interval running exercise on physical and cognitive performance, mood, and affect and underlying neurophysiological factors during a terrestrial simulated space mission.

Removing Pollutants from Sewage Waters with Ground Apricot Kernel Shell Material.

For the first time, a comprehensive review of the literature data on the use of apricot () biomass components as a sorption material for the treatment of wastewater and environmental water from various pollutants is carried out in the present study. In addition to a comprehensive analysis of contemporary studies, the current work carried out its own microstructural and energy dispersive studies. It shows that apricot kernel shell is a promising raw material for obtaining sorption materials that can be used to extract various pollutants from aqueous media.

[Influence of N-alkynylaminosteroids on mitochondria function and autophagy in glioma cells].

In this work we examined the synthesized N-alkynyl-17-aminosteroids and N-alkynyl-20-aminosteroids (based on dehydroepiandrosterone and pregnenolone, respectively) for their effect on C6 rat glioma cell functions. At 10 μM, the compounds had an insignificant effect on C6 glioma mitochondrial membrane potential, but increased cell autophagy by 70-90%, comparable to the known autophagy inducer dexamethasone. Docking simulations predict a potential high-affinity interaction between N-alkynylaminosteroids and Keap1 and the Hedgehog pathway protein, Smoothened, which are involved in autophagy regulation.

Mass balance of complementary metasomatic processes using isocon analysis.

This study develops a method to estimate the redistribution of elements during several associated metasomatic processes simultaneously involved in the formation of a geological complex The method is based on classical mass balancing using isocon analysis. The proposed approach is applicable if geological prerequisites indicate that (a) the metasomatic rocks inherited some components (, etc.) from one of the earlier rocks of the studied complex; (b) these components have been transported by a fluid; and (c) this saturated fluid has produced several varieties of metasomatic rocks rich in components , etc.

Specific features of rational pharmacotherapy in elderly patients.

Objective: It is well-known that finding an optimum medication at the correct dose for elderly patients is challenging for the practitioner. This study aimed to examine the main trends in prescribing medications for elderly patients and their compliance with the principles of rational pharmacotherapy, and to establish the main factors affecting adherence to treatment in these patients.

Methods: 956 records of outpatients over 60 years of age were examined.

Post-COVID worsening of a Parkinson's disease patient.

Worsening of clinical symptoms after COVID-19 infection and misregulation of CD4 and CD8 T-cell numbers may be revealed in PD patients. Immunological changes may be a source of clinical worsening of the patient.

[Endovascular treatment of women with pelvic varicose veins due to post-thrombotic iliac vein lesion].

Background: Post-thrombotic iliac vein lesion is one of the causes of secondary pelvic varicose veins (PVV) in women. Endovascular treatment of this cohort of patients requires further studies.

Aim: The study was undertaken to investigate the aspects of endovascular treatment of female patients diagnosed as having PVV secondary to post-thrombotic alterations of the iliac veins.

[Method of determining disease severity in women with pelvic varicose veins].

Background: Using assessment scales in clinical and research practice is one of fundamental reference methods of evaluation in human pathological states. Pelvic vein varicosity is an independent nosological entity within the framework of chronic vein diseases. Currently, the clinical methods of assessment in the aspect of a patient-oriented approach in this type of disease are largely understudied and still not duly defined.

Genetic Differentiation of the Steppe Field Mouse Sylvaemus witherbyi Populations: The Results of the Mitochondrial DNA Control Region Analysis.

The degree of genetic diversity of the steppe field mouse was estimated on the basis of the mtDNA control region variability data. Polymorphism of this mtDNA marker in S. witherbyi was more pronounced than previously assumed.

[Ultrasonographic examination of major veins of lower limbs and pelvic veins in pregnant women].

The problem of chronic venous insufficiency in women during pregnancy is of current concern. A total of 115 pregnant women in the first, second and third trimesters of gestation were examined in a stage-wise manner. During the first stage we conducted a comprehensive clinical study with the obligatory consultation by the obstetrician-gynaecologist.

[The application of the 'Biometriclal Dactylography 17.0' program complex for the digital interpretation of the finger dermatoglyphic features].

The objective of the present study was the development of the computer software for the scale-free interpretation of the finger dermatoglyphic features needed for the objective comprehensive evaluation of their principal characteristics in the digital terms. We have elaborated the program complex making it possible to address the following problems: thr formulation of the database of electronic copies of the finger print and toe print images in the family groups, the display of the finger print and toe print images on the screen, marking the points and lines for automated readout of digital angular and metric information or automated calculation of relative values, the formulation of the database of digital information about the papillary patterns on the fingers and toes in the family triplets (farther + mother + child) and its import into an Excel file.

One-Year Mission on ISS Is a Step Towards Interplanetary Missions.

Background: in the 1990s Russian cosmonauts performed six long-duration missions on Mir that went from 312 to 438 d. In 2015 a mission on the International Space Station that continued for 340 d, 8 h, and 47 min was successfully accomplished. It was a joint U.

The effect of long-term confinement and the efficacy of exercise countermeasures on muscle strength during a simulated mission to Mars: data from the Mars500 study.

Background: Isolation and long duration spaceflight are associated with musculoskeletal deconditioning. Mars500 was a unique, high-fidelity analogue of the psychological challenges of a 520-day manned mission to Mars. We aimed to explore the effect of musculoskeletal deconditioning on three outcome measures: (1) if lower limb muscle strength was reduced during the 520-day isolation; (2) if type I or II muscle fibres were differentially affected; and (3) whether any 70-day exercise interventions prevented any isolation-induced loss of strength.

Locomotion Strategy and Magnitude of Ground Reaction Forces During Treadmill Training on ISS.

Introduction: Creation of the cosmonaut in-flight physical training process is currently based on the leading role of support afferents in the development of hypogravity changes in the motor system. We assume that the strength of support afferents is related to the magnitude of the ground reaction forces (GRF). For this purpose it was necessary to compare the GRF magnitude on the Russian BD-2 treadmill for different locomotion types (walking and running), modes (active and passive), and subjects.

Memorization of Sequences of Movements of the Right or the Left Hand by Right- and Left-Handers: Vector Coding.

In order to test the hypothesis of hemisphere specialization for different types of information coding (the right hemisphere, for positional coding; the left one, for vector coding), we analyzed the errors of right and left-handers during a task involving the memorization of sequences of movements by the left or the right hand, which activates vector coding by changing the order of movements in memorized sequences. The task was first performed by the right or the left hand, then by the opposite hand. It was found that both'right- and left-handers use the information about the previous movements of the dominant hand, but not of the non-dom" inant one.

[The point-digital interpretation and the choice of the dermatoglyphic patterns on human fingers for diagnostics of consanguineous relationship].

The objective of the present study was the development of the point-digital model for the scaless interpretation of the dermatoglyphic papillary patterns on human fingers that would allow to comprehensively describe, in digital terms, the main characteristics of the traits and perform the quantitative assessment of the frequency of their inheritance. A specially developed computer program, D.glyphic.

[Comparative Analisys of Efficacy of Countermeasure Provided by Different Modes of Locomotor Training in Space Flight.].

According to the results of the experiment performed on the ISS with participation of 15 Russian cosmonauts was fulfilled the comparative analysis of two models of preventive measures used by the Russian members of the long term space flight: the intense interval training in the aerobic-anaerobic zone power (recommended model) and the continuous low-intensity exercise in the aerobic zone energy power of the muscle activity. The interval trainings in the conditions of the space flight have provided the maintenance of the level of physical performance close to the preflight level; characterized by the maximum running speed, physiological value of work and lactate level after a standard load. The putative mechanisms of counteraction to adaptive remodeling of the propulsion system in zero gravity and enhanced understanding of the laws governing the interaction of the human body with the gravitational field of the Earth are described in the paper.

[On the orientation of palmar whorl patterns].

The objective of the present work was to study the palmar whorl patterns for the inclusion them in the scope of dermatoglyphic signs along with the arc and loop patterns having a well apparent structural organization. For the first time in the history of domestic dermatoglyphic studies, we described the structure of palmar whorl patterns (based on the palmar prints obtained from 555 subjects) with respect to the surrounding tri-radii. Moreover, the role of their radiants in the formation of node orientation was considered.