[The effect of nerve growth factor, guanethidine and their combined use on nuclease activity in animal tissues].

Activity of ribo- and deoxyribonucleases RNAases I and II, DNAases I and II was studied in brain hemispheres, liver, kidney and heart tissues of one-month-old rats, which were administered daily, beginning from birth either with nerve growth factor 15 micrograms/kg, guanethidine 30 micrograms/kg or with these compounds simultaneously at the doses mentioned above. Activity of the nucleases studied was altered in nervous tissue and in vegeto-dependent tissues after separate treatment with both nerve growth factor and guanethidine, while their simultaneous administration caused slight normalization but not to complete recovery of the patterns studied.

[Effectiveness of essentiale and vitohepatum as stabilizers of liver lysosomal membranes].

Essentiale or vitohepatum were administered into 26-28 months old Wistar rats to stabilize the lysosomal membranes. Administration of essentiale (cyancobalamine standardization at a dose of 0.286 microgram/kg) within 21 days led to a decrease in total activity of acid DNAase, acid phosphatase, cathepsin D, hyaluronidase without distinct changes in acid RNAase activity.

[Deoxyribonuclease activity in the tissues of X-ray irradiated animals with alloxan diabetes].

Fractionated X-irradiation (a cumulative dose of 12.9 mC/kg) of animals with alloxan diabetes caused different, with respect to direction and degree, changes in liver nuclease system than those observed in intact animals after similar irradiation. This indicates that insulin is involved in a metabolic response of the organism to irradiation with relatively small doses.