The Gypsum Influence on the Formation of Secondary Phases During Autoclave Leaching of Gold-Bearing Concentrates and the Silver Recovery Using Cyanidation.

Autoclave leaching of sulfide concentrates may produce various ferric secondary phases, depending on the arsenic content and temperature. Silver is converted to argentojarosite, from which it is not recoverable by standard cyanidation methods. To increase silver recovery, it is necessary to reduce the argentojarosite formation during autoclave leaching.

Galectin-3 in Blood Serum and Lymphocytes as a Marker of Myocardial Damage in Patients with Arterial Hypertension and COVID-19.

Background: The constant increase of arterial hypertension and the development of pathology at an earlier age are global healthcare problems that cause damage to vital organs and worsen patient prognosis. In recent years, studies have shown that galectin-3 plays a role in the development and progression of arterial hypertension and coronavirus disease (COVID-19).

Objective: The explanatory research study aimed to analyze the prognostic value of galectin-3 determination in the serum blood and lymphocytes of patients with arterial hypertension and coronavirus disease (COVID-19).

Iridium Complexes with BIAN-Type Ligands: Synthesis, Structure and Redox Chemistry.

A series of iridium complexes with bis(diisopropylphenyl)iminoacenaphtene (dpp-bian) ligands, [Ir(cod)(dpp-bian)Cl] (), [Ir(cod)(NO)(dpp-bian)](BF) () and [Ir(cod)(dpp-bian)](BF) (), were prepared and characterized by spectroscopic techniques, elemental analysis, X-ray diffraction analysis and cyclic voltammetry (CV). The structures of - feature a square planar backbone consisting of two C = C π-bonds of 1,5-cyclooctadiene (cod) and two nitrogen atoms of dpp-bian supplemented with a chloride ion (for ) or a NO group (for ) to complete a square-pyramidal geometry. In the nitrosyl complex , the Ir-N-O group has a bent geometry (the angle is 125°).

Novel Copper(II) Complexes with Dipinodiazafluorene Ligands: Synthesis, Structure, Magnetic and Catalytic Properties.

The reactions of CuX (X = Cl, Br) with dipinodiazafluorenes yielded four new complexes [CuXL] (X = Cl (), Br (), L = (1R,3R,8R,10R)-2,2,9,9-Tetramethyl-3,4,7,8,9,10-hexahydro-1H-1,3:8,10-dimethanocyclopenta [1,2-b:5,4-b']diquinolin-12(2H)-one) and [(CuX)L]n (X = Cl (), Br (), L = (1R,3R,8R,10R,1'R,3'R,8'R,10'R)-2,2,2',2',9,9,9',9'-Octamethyl-1,1',2,2',3,3',4,4',7,7',8,8',9,9',10,10'-hexadecahydro-1,3:1',3':8,10:8',10'-tetramethano-12,12'-bi(cyclopenta [1,2-b:5,4-b']diquinolinylidene). The complexes were characterized by IR and EPR spectroscopy, HR-ESI-MS and elemental analysis. The crystal structures of compounds , and were determined by X-ray diffraction (XRD) analysis.

Jaw tracking integration to the virtual patient: A 4D dynamic approach.

This dental technique describes a novel cost-effective workflow for integrating mandible kinematics into a static virtual patient. Computed tomography data are segmented and merged with intraoral surface scans and a target tracking video reproducing the mandible movements. A 4-dimensional dynamic virtual patient is created by using an open-source software program, and all patient-specific parameters can be exported for individualization of a virtual or analog articulator.

Heteroleptic Pd(II) and Pt(II) Complexes with Redox-Active Ligands: Synthesis, Structure, and Multimodal Anticancer Mechanism.

A series of heteroleptic square-planar Pt and Pd complexes with bis(diisopropylphenyl) iminoacenaphtene (dpp-Bian) and Cl, 1,3-dithia-2-thione-4,5-dithiolate (dmit), or 1,3-dithia-2-thione-4,5-diselenolate (dsit) ligands have been prepared and characterized by spectroscopic techniques, elemental analysis, X-ray diffraction analysis, and cyclic voltammetry (CV). The intermolecular noncovalent interactions in the crystal structures were assessed by density functional theory (DFT) calculations. The anticancer activity of Pd complexes in breast cancer cell lines was limited by their solubility.

Novel Oxidovanadium Complexes with Redox-Active R-Mian and R-Bian Ligands: Synthesis, Structure, Redox and Catalytic Properties.

A new monoiminoacenaphthenone 3,5-(CF)CH-mian (complex ) was synthesized and further exploited, along with the already known monoiminoacenaphthenone dpp-mian, to obtain oxidovanadium(IV) complexes [VOCl(dpp-mian)(CHCN)] () and [VOCl(3,5-(CF)CH-bian)(HO)][VOCl(3,5-(CF)CH-bian)]·2.85DME () from [VOCl(CHCN)(HO)] () or [VCl(THF)]. The structure of all compounds was determined using X-ray structural analysis.

[Comprehensive treatment of a child with an extensive composite odontoma].

Odontoma make up about 22% of all odontogenic tumors. Diagnosis and treatment of odontoma in children has a number of features: the variability of the clinical and X-ray picture, the appearance of signs during the period of changing teeth, retention or the difficulty of the eruption of complete teeth in the affected area. In the process of growth odontoma can cause significant deformation of the jaw bones.

The association of aрai-polymorphism of vitamin D receptor gene (VDR) with development of generalized parodontitis in Ukrainian population.

Objective: Introduction: At present, it is believed that the genetic component is important in the pathogenesis of periodontitis. One of the candidate genes that are of major importance in the development of the disease is the vitamin D receptor gene (VDR). The association of its genetic polymorphisms, in particular Apal, with periodontitis in different populations of the world is proved.

Hydrogen Sulfide Releasing 2-Mercaptoacrylic Acid-Based Derivative Possesses Cytoprotective Activity in a Small Intestine of Rats with Medication-Induced Enteropathy.

Small intestinal injury is known to be one of the most commonly appearing pathologies, resulting in the use of medications such as: nonsteroidal anti-inflammatory drugs (NSAIDs), antitumor drugs and angiotensin-converting enzyme (ACE) inhibitors. The principal objective of this study is to evaluate the action of a novel mercaptoacrylic acid derivative able to release H₂S on parameters of NO-synthase system and oxidative stress. Inducing enteropathy, three types of medications were used: indomethacin, an NSAID (35 mg/kg); methotrexate, an antitumor drug (10 mg/kg); and enalapril, an ACE inhibitor (2 mg/kg/day).

[Role of cyclooxygenase in modification of intestinal microflora under stress condition].

Stress and nonsteroidal anti-inflammatory drugs, which act as nonselective inhibitors of cyclooxygenase, are the main factors of ulcerogenesis in digestive system. However, the peculiarities of their combined action upon the status of intestinal microflora and the parameters of NO-synthase system are still poorly understood. In experiments with rats we show that water-restrained stress was accompanied by a considerable increase of iNOS activity and intensity of lipoperoxidation processes.

Effects of conventional and hydrogen sulfide-releasing non-steroidal anti-inflammatory drugs in rats with stress-induced and epinephrine-induced gastric damage.

Mechanisms of gastric defence under conditions of combined influence of acute stress and non-steroidal anti-inflammatory drugs (NSAIDs) are still poorly studied. The aim of this study was to explore the effects of different types of NSAIDs (naproxen, celecoxib and ATB-346) in producing experimental gastric lesions (induced by water-restraint stress (WRS) or by epinephrine (EPN) injection) and to determine the role of lipid peroxidation and the nitric oxide (NO) system in the pathogenesis of the damage. Male rats were used (eight per group) in this work.

[Parameters of NO synthase system of gastric mucosa in rats under stress conditions and inhibition of cyclooxygenase].

In experiments on rats with modeled water-restrained stress, the influence of nonsteroidal anti-inflammatory drugs of different genesis on morphological status of gastric mucosa and changes of NO-synthase system parameters have been studied Administration of nonselective cyclooxygenese inhibitor naproxen in the water-restrained stress model in rats potentiated the increase of severity of damage of gastric mucosa. At the same time, the activity of both inducible and constitutive isoforms ofNO-sythase decreased. The parameters of lipoperoxidation remained at the level observed during water-restrained stress.

Role of nitric oxide-synthase and cyclooxygenase/lipooxygenase systems in development of experimental ulcerative colitis.

Development of ulcerative colitis was accompanied by the activation of iNOS/COX-2/5-LOX and increased contents of nitric oxide (NO), prostaglandin E₂ (PGE₂), and leukotriene B₄ (LTB₄). The following information was assessed: morphological changes, activity of nitric oxide-synthase, content of nitric oxide, and indexes of lipoperoxidation processes in the mucous membrane of the large intestine (MMLI). Colitis was induced in rats by intrarectal administration of 1 ml of 4% acetic acid.

[Plasty of extrahepatic biliary ducts with the use of ileal autotransplantate].

A method of extrahepatic biliary duct plasty with the use of tubular ileal autotransplantate of 1 sm in diameter was presented in 19 patients with benign strictures. The transplantate on the vascular pedicle was created by resection of the antimesenterial side of the intestinal loop. Distally the anastomosis was performed with the common bile duct, including, thus, papilla Vateri into the bile passage (4 patients).

Robust regression for high throughput drug screening.

Effective analysis of high throughput screening (HTS) data requires automation of dose-response curve fitting for large numbers of datasets. Datasets with outliers are not handled well by standard non-linear least squares methods, and manual outlier removal after visual inspection is tedious and potentially biased. We propose robust non-linear regression via M-estimation as a statistical technique for automated implementation.

[Importance of urgent histological investigation in surgical treatment of biliopancreatoduodenal zone carcinoma].

Urgent intraoperative investigation allows a surgeon, depending on the morphological conclusion, to conduct individual surgical intervention in the form of anastomosis with penetration into the tissue of the pancreas. The method decreases the rate of surgical complications, improves immediate results of patient treatment and reduces postoperative lethality. This proves the importance of morphology in the surgical treatment of tumours in the zone concerned.

[Features of glutamate dehydrogenase in fetal and adult rumen tissue].

Glutamate dehydrogenase (GDH) from rumen mucosa of cow fetus, liver and two forms from mucosa (bacterial and tissue) of the adult animal were partly purified and characterized. The activity of the bacterial glutamate dehydrogenase was shown to depend on qualities of a biomass of microbes, adhered on surface of rumen mucosa. All enzymes from tissues (GDHTRF, TRC, TLC), revealed the hypersensibility to increase in the concentration medium of Zn2+, guanosine triphosphate (GTP), acting here in a role of negative modulators, and also adenosine monophosphate (AMP) and leucine, which acted as activators.

[Surgical treatment of heart myxomas].

Nine persons were operated on in the Samara Interregional Cardiosurgical Center for left atrial myxoma in 1986-1991. Two-dimensional echocardiography was the major technique in making a correct diagnosis. The tumor was found in one patient intraoperatively.

[10-year experience with correction of supraventricular tachycardia].

The results of a 10-year experience in surgical treatment of supraventricular tachyarrhythmias in 258 patients are analysed. Invasive and noninvasive methods of electrophysiological studies with the predominant use of Soviet-produced apparatuses were employed in establishing the diagnosis. Surgery of arrhythmias included catheter destruction, cryosurgery on a working heart, but the prevailing methods were various types of destruction of anomalous conducting paths under conditions of extracorporeal circulation.