[Hysterectomi - there is now a fourth minimally invasive method].

For hysterectomy minimally invasive methods offer benefits.  A newly developed procedure with great potential is at hand.  Insufficient surgical training is a problem.

New concepts and trends in vaginal prolapse surgery.

Despite poor results in prolapse surgery, the operative procedures have basically remained unchanged for 100 years. It has been postulated that lifting restrictions and other measures of inactivation are crucial for the success. Even though most of what is done in prolapse repair is not evidence based, few have challenged the prevailing concepts.

Necrotizing fasciitis following transobturator tape treated by extensive surgery and hyperbaric oxygen.

The transobturator sling procedure (TVT-O) was developed to minimize surgical risks involved in treating genuine stress incontinence. All data suggest that most risks associated with the retropubic route such as injuries to the bladder, intestines or vessels are practically obsolete with the obturator route. However, severe soft-tissue infections have been reported with this new technique.

Sedation and local anaesthesia for vaginal pelvic floor repair of genital prolapse using mesh.

In this study of the surgical repair of pelvic organ prolapse (POP), the vaginal pelvic floor repair with mesh (PFR-Mesh) procedure was used. The procedure is originally named TVM. All 55 patients in the series were operated upon under sedation and local anaesthesia as pain relief.

[Experiences from a new surgical unit. New approach in prolapse surgery has eliminated the waiting list].

A unit specializing in the surgical repair of vaginal vault prolapse was formed. The objective was to treat all kinds of defects in local anaesthesia with a hospital stay not exceeding 24 hours. Almost 800 women have been operated upon in the manner outlined in less than 26 months time.

A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes.

DNA methylation is a covalent modification of the nucleotide cytosine that is stably inherited at the dinucleotide CpG by somatic cells, and 70% of CpG dinucleotides in the genome are methylated. The exception to this pattern of methylation are CpG islands, CpG-rich sequences that are protected from methylation, and generally are thought to be methylated only on the inactive X-chromosome and in tumors, as well as differentially methylated regions (DMRs) in the vicinity of imprinted genes. To identify chromosomal regions that might harbor imprinted genes, we devised a strategy for isolating a library of normally methylated CpG islands.